About 16% of the world’s population lives with insomnia. There are a number of different methods a person may use to help them improve their sleep quality, such as taking melatonin supplements. Past studies show there are some potential risks to taking melatonin supplements. A new study reports that long-term use of melatonin supplements may […]
Long-term melatonin use linked to 90% greater heart failure risk – Read More »
by Gillian Rutherford, University of Alberta edited by Gaby Clark, reviewed by Andrew Zinin Editors’ notes Graphical abstract. Credit: Cell Reports Medicine (2025). DOI: 10.1016/j.xcrm.2025.102449. https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00522-1 Research published today in Cell Reports Medicine reveals key biological differences that may explain why women with long COVID—especially those who develop chronic fatigue syndrome—tend to experience more severe and persistent symptoms than men do. Post COVID-19
Women are three times more likely than men to get severe long COVID: Here’s why Read More »
by Linsey Covino-Deaso, Children’s Hospital Boston edited by Lisa Lock, reviewed by Robert Egan Editors’ notes Credit: Cell (2025). DOI: 10.1016/j.cell.2025.06.033 It started with wine. Or more precisely, a conversation about it. “My colleagues and I were talking about how some people think drinking wine may be anti-inflammatory,” recalls Xu Zhou, Ph.D., from the Division of Gastroenterology, Hepatology, and Nutrition
A toast to BRD4: How acidity changes the immune response Read More »
by American Society of Nephrology edited by Stephanie Baum, reviewed by Robert Egan Editors’ notes Credit: CC0 Public Domain New research reveals that contrary to conventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients. The
Study uncovers glomerular disease outcomes across the lifespan Read More »
by George Institute for Global Health edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Credit: Pixabay/CC0 Public Domain The results of two large-scale studies demonstrate that sodium-glucose co-transporter 2 (SGLT2) inhibitors significantly reduce the risk of kidney disease progression, hospitalization, and death in people with and without diabetes, regardless of their kidney function. In late-breaking presentations
Routine use of metabolic drug recommended for all kidney function levels Read More »
by NYU Langone Health edited by Gaby Clark, reviewed by Robert Egan Editors’ notes Credit: Unsplash/CC0 Public Domain Record numbers of men and women globally are now estimated to have reduced kidney function, a new study shows. Figures rose from 378 million people with the disease in 1990 to 788 million in 2023 as the world population grew
Chronic kidney disease is now the ninth leading cause of death, global analysis finds Read More »
by Society of Nuclear Medicine and Molecular Imaging edited by Gaby Clark, reviewed by Andrew Zinin Editors’ notes Graphical Abstract: Schematic representation of 3-step HER2-targeted 225Ac-PRIT, 225Ac-PRIT treatment of BT-474 human breast cancer cell derived xenograft, and representative histologic images of kidneys stained with hematoxylin and eosin, taken from treated mice at 175 days (top: untreated control; bottom: 2 x 225Ac-PRIT [37 kBq
Carla Cantor November 06, 2025 A reanalysis of a pivotal antidepressant trial suggested that the selective serotonin reuptake inhibitor (SSRI) sertraline may ease key symptoms of depression and anxiety within 2 weeks of treatment — effects that the primary analysis missed. The secondary analysis of the landmark Prescribing ANtiDepressants Appropriately (PANDA) trial, which examined the
PANDA Revisited: Sertraline’s Early Benefit Missed Read More »
by Whitehead Institute for Biomedical Research edited by Stephanie Baum, reviewed by Robert Egan Editors’ notes In many cases, one gene can produce multiple versions of a protein. Rare diseases may present differently in people for whom one or more versions of the protein are still produced versus in people for whom all versions of the protein are
by Justin Jackson, Medical Xpress edited by Gaby Clark, reviewed by Robert Egan Editors’ notes Secondary end point—UA alters inflammatory immune response. Credit: Nature Aging (2025). DOI: 10.1038/s43587-025-00996-x An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation
Urolithin A nudges aging immune cells toward a youthful profile in 28 days Read More »
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