November 10, 2025

De-escalating GLP-1s to Every-2-Weeks Maintenance Option

November 10, 2025 / Clinical Practice / InnovateMed Author / GLP1

Miriam E. Tucker November 05, 2025 ATLANTA — De-escalating GLP-1 therapy from weekly to every-other-week dosing following weight normalization may be an effective strategy for maintaining both weight and metabolic improvements, new findings suggested. “In my clinical experience, people who first reach a normal weight and improve their metabolic health following standard weekly dosing of […]

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With Phase 3 Completed, Obesity Pill Orforglipron Advances

November 10, 2025 / Research update / InnovateMed Author / obesity pill

Miriam E. Tucker November 06, 2025 ATLANTA — Eli Lilly’s investigational oral GLP-1 drug orforglipron produced significant weight loss, A1c reduction, and cardiovascular risk factor improvements in the company’s Phase 3 ATTAIN-2 trial of adults with both obesity and type 2 diabetes (T2D). Orforglipron is a once-daily small molecule (nonpeptide) that, unlike the current oral

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 DREAMS A $25 shot to prevent HIV?

November 10, 2025 / News update / InnovateMed Author / HIV

A shot so inexpensive that it could eradicate HIV worldwide — and still be profitable? It’s less farfetched than it might sound. STAT’s esteemed Ed Silverman talked with a pharmacology professor with high hopes for Gilead Sciences’ groundbreaking HIV prevention drug. Gilead has told Wall Street analysts that about 90% of the targeted patient population should

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How diet affects aging metabolism differently for men and women

November 10, 2025 / Research update / InnovateMed Author / metabolism

By Dr. Liji Thomas, MDReviewed by Lauren HardakerNov 7 2025 Researchers have uncovered striking sex-based differences in how diet influences metabolism with age, revealing that plant proteins and whole grains enhance men’s insulin sensitivity, while moderate wine consumption benefits women. Study: Sex Differences in Associations Between Diet and Metabolic Health in Older Adults: The Roles of Vegetable Protein

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Researchers uncover how brain lipids help neurons communicate and protect themselves

November 10, 2025 / Research update / InnovateMed Author / brain lipids

A University of Alberta research team has discovered a new function for brain molecules known as gangliosides, offering potential new targets for the treatment of Huntington’s and other genetic neurological diseases. In their paper published in Science Advances, the team shows that gangliosides are key to the formation and release of extracellular vesicles, tiny particles that mediate cell communication

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Scientists uncover key mechanisms that drive an enzyme linked to aging and cancer

November 10, 2025 / Research update / InnovateMed Author / aging

A tandem allosteric effect has been discovered that helps Sir2, a key enzyme for many biological processes, efficiently deacetylate proteins Peer-Reviewed Publication Institute of Science Tokyo image: Allosteric conformations of CBL, induced by the reactant and product, accelerate the Sir2 deacetylation cycle. view more Credit: Institute of Science Tokyo, Japan Sir2, an enzyme belonging to sirtuins,

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Researchers develop a potential IVIG replacement for treating autoimmunity that’s significantly more potent

November 10, 2025 / Research update / InnovateMed Author / autoimmunity

The discovery could greatly improve patient experience and address supply shortages. Peer-Reviewed Publication Rockefeller University image: A histology showing the ankle joint of a mouse four days after receiving the new antibody treatment, V11 sFc. view more Credit: Ravetch lab at The Rockefeller University Intravenous immunoglobulin (IVIG) therapy involves infusing patients with naturally occurring IgG

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