Alzheimer’s disease

Menopause, hormones and the brain: How hormone therapy could help protect against Alzheimer’s

by George E. Barreto, Miguel G. Borda, The Conversation edited by Gaby Clark, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Credit: Anna Shvets from Pexels As dementia and other neurodegenerative diseases become more common worldwide, researchers are searching urgently for ways to protect the brain as we age. One area attracting growing attention […]

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A simple blood test could change how Alzheimer’s is diagnosed

by Vittoria D’Alessio, Horizon: The EU Research & Innovation Magazine edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain A blood test, combined with an ultrathin material derived from graphite, could significantly advance efforts to detect Alzheimer’s disease at its very earliest stage, even before symptoms appear.

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Successful 40-Hz auditory stimulation in aged monkeys suggests potential for noninvasive Alzheimer’s therapy

by Zhang Nannan, Chinese Academy of Sciences edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source 40-Hz auditory stimulation specifically caused a significant increase of more than 200% in Aβ42 and Aβ40 protein levels in the CSF of aged monkeys, which persisted for more than 5 weeks. Credit: KIZ A research

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Most Alzheimer’s cases linked to variants in a single gene

   Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain Potentially more than 90% of Alzheimer’s disease cases would not occur without the contribution of a single gene (APOE), according to a new analysis led by UCL researchers. The scientists also found that close to half of all dementia cases would probably

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Protein disposal system may accelerate Alzheimer’s by transferring toxins between brain cells

by Technion – Israel Institute of Technology edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Evidence of direct interaction between SQSTM1/p62 and UBB+1. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2504528122 A research group led by Professor Michael Glickman, dean of Technion’s Faculty of Biology, has uncovered a key mechanism in the development of Alzheimer’s.

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Arginine supplementation curbs Alzheimer’s disease pathology in animal models

Researchers show that oral arginine reduces amyloid buildup and neuroinflammation, offering a safe, low-cost therapeutic approach for Alzheimer’s disease Peer-Reviewed Publication Kindai University image: Researchers at Kindai University have discovered that oral administration of arginine, a naturally occurring amino acid, can suppress amyloid β (Aβ) aggregation and alleviate neurological symptoms in animal models of Alzheimer’s

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Astrocytes clear amyloid plaques and preserve cognitive function in Alzheimer’s mouse models

by Baylor College of Medicine edited by Robert Egan  Editors’ notes An astrocyte cell grown in tissue culture stained with antibodies to GFAP and vimentin. Credit: Wikimedia Commons / GerryShaw, CC BY-SA 3.0 Researchers at Baylor College of Medicine have discovered a natural mechanism that clears existing amyloid plaques in the brains of mouse models of Alzheimer’s disease

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Microglia modulate the reactivity of astrocytes in Alzheimer’s disease, study finds

by Ingrid Fadelli, Medical Xpress edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Image illustrates that astrocyte reactivity associates with amyloid-β only when microglia are reactive. As shown, the brain surface on the left (microglia non-reactive group) appears blank, whereas the right panel (microglia reactive group) displays multiple significant blue regions, indicating this association. Credit: Ferrari-Souza,

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Clogged ‘drains’ in the brain likely an early-warning sign of Alzheimer’s disease

by Nanyang Technological University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Associate Professor Nagaendran Kandiah (right) from Nanyang Technological University, Singapore, and Justin Ong, a medical student from the University, are part of the research team which discovered that “drains” in the brain, responsible for clearing toxic wastes in the organ, tend to get clogged

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Muscle protein linked to exercise opens new way to treat Alzheimer’s

Florida Atlantic University image: The study in mice showed that exercise boosts the muscle protein Ctsb, protects memory, and supports cognitive function. view more  Credit: Alex Dolce, Florida Atlantic University Alzheimer’s disease (AD) is a devastating cause of memory loss and cognitive decline, for which no curative treatment is available. Among lifestyle factors, physical activity stands

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