Genetics

Gene therapy may cure diabetic heart disease, mouse study shows

by Nature Publishing Group edited by Lisa Lock, reviewed by Robert Egan Editors’ notes A hypothetical mechanism of the glycophagy role in physiology and pathology involvement in diabetic heart disease. Credit: Nature Cardiovascular Research (2025). DOI: 10.1038/s44161-025-00726-x Scientists have reversed diabetic heart failure with a genetic therapy in mice and miniature human “hearts” grown from stem cells. The new gene […]

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Study ties genetics and common anticoagulant to risk of intracranial hemorrhage

September 3, 2025 / Genetics, Research update / InnovateMed Author / common anticoagulant, intracranial hemorrhage

by Yale School of Medicine edited by Sadie Harley, reviewed by Andrew Zinin A 12 lead ECG showing atrial fibrillation at approximately 150 beats per minute. Credit: James Heilman, MD/Wikipedia/CC BY-SA 3.0 A study published in JAMA Neurology found that patients with atrial fibrillation who were treated with Eliquis (apixaban) and carry the APOE e4 genetic allele have a higher

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Progress in gene therapy offers hope for long-term knee pain relief

July 30, 2025 / Gene Therapy, Genetics, Research update / InnovateMed Author / knee pain

edited by Sadie Harley, reviewed by Andrew Zinin Credit: Towfiqu barbhuiya from Pexels For nearly three decades, Mayo Clinic researcher Christopher Evans, Ph.D., has pushed to expand gene therapy beyond its original scope of fixing rare, single-gene defects. That has meant systematically advancing the field through laboratory experiments, pre-clinical studies and clinical trials. Several gene therapies have

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Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

June 17, 2025 / Genetics, Integrative exome sequencing, Research update / InnovateMed Author / machine learning, systemic sclerosis

by Molly Chiu, Baylor College of Medicine edited by Robert Egan Editors’ notes Graphical abstract. Credit: Annals of the Rheumatic Diseases (2025). DOI: 10.1016/j.ard.2025.05.009 Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been identified, but others remain unknown, which has impeded the development of targeted treatments. In a new study published in Annals

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Gene therapy may cure diabetic heart disease, mouse study shows

Study ties genetics and common anticoagulant to risk of intracranial hemorrhage

Progress in gene therapy offers hope for long-term knee pain relief

Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

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