PANDA Revisited: Sertraline’s Early Benefit Missed

Carla Cantor November 06, 2025 A reanalysis of a pivotal antidepressant trial suggested that the selective serotonin reuptake inhibitor (SSRI) sertraline may ease key symptoms of depression and anxiety within 2 weeks of treatment — effects that the primary analysis missed. The secondary analysis of the landmark Prescribing ANtiDepressants Appropriately (PANDA) trial, which examined the […]

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