July 30, 2025

Progress in gene therapy offers hope for long-term knee pain relief

edited by Sadie Harley, reviewed by Andrew Zinin Credit: Towfiqu barbhuiya from Pexels For nearly three decades, Mayo Clinic researcher Christopher Evans, Ph.D., has pushed to expand gene therapy beyond its original scope of fixing rare, single-gene defects. That has meant systematically advancing the field through laboratory experiments, pre-clinical studies and clinical trials. Several gene therapies have […]

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Intermittent Fasting and Type 2 Diabetes: When to Recommend and When to Avoid This Eating Plan

Intermittent fasting has gained popularity among individuals who want to lose weight. While this approach has shown promising results, it may not be the best eating plan for everyone. When discussing weight loss options with your patients, some may show interest in intermittent fasting. It’s important to note that individuals with type 2 diabetes should only

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Can Blocking AMH Reverse PCOS? New Study Says Yes – endocrinology & metabolism

Researchers from the French National Institute of Health & Medical Research (Inserm), University of Lille in Lille, France, and the university’s teaching hospital CHU de Lille have identified a promising new therapeutic strategy for polycystic ovary syndrome (PCOS). In preclinical models, the use of antibodies that block the activity of anti-Müllerian hormone (AMH) helped prevent

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Microcone-enhanced microfluidic device captures circulating tumor cells efficiently

Chiba University 29, 2025 Circulating tumor cells (CTCs) refer to cancer cells that have broken off from a primary tumor. These tumor cells can travel through the blood in the circulatory system and lodge themselves in other organs to cause secondary tumors. Therefore, the detection and subsequent characterization of CTCs from blood can help in

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Antiviral treatment fails to slow early-stage Alzheimer’s

by Columbia University Irving Medical Center edited by Stephanie Baum, reviewed by Andrew Zinin Credit: Pixabay/CC0 Public Domain The idea that herpes infections trigger or contribute to Alzheimer’s disease has been gaining favor among some scientists, raising hope that herpes treatments could slow the progression of Alzheimer’s symptoms among patients. But the first clinical trial to test that

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Mexican neuroscientist identifies glutamate biomarker predicting schizophrenia treatment success

Dr. Camilo de la Fuente-Sandoval transforms early psychosis care through neuroimaging breakthroughs Reports and Proceedings Genomic Press image: Camilo de la Fuente-Sandoval, MD, PhD, Instituto Nacional de Neurología y Neurocirugía, Mexico view moreCredit: Camilo de la Fuente-Sandoval, MD, PhD, Instituto Nacional de Neurología y Neurocirugía, Mexico MEXICO CITY, MEXICO, 29 July 2025 — In a

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Spectacular breakthrough in sepsis research: Vitamin B1 stops deadly lactate production and opens the door to a new treatment

  Vlaams Instituut voor Biotechnologie Ghent, July 29, 2025 – Scientists in Ghent have achieved a major breakthrough in sepsis research. In a study on mice, the researchers demonstrate that vitamin B1 (thiamine pyrophosphate, TPP) restores mitochondrial energy metabolism, drastically reduces lactate production, and increases survival rates in sepsis. The study results were published in Cell Reports.

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Unmet potential: How ALS patients and caregivers are missing out on accessibility features in everyday technology

Peer-Reviewed Publication Toho University image: Associate Professor Takehisa Hirayama, lead author of the study, Department of Neurology, Toho University School of Medicine. view moreCredit: Takehisa Hirayama A recent study by Associate Professor Takehisa Hirayama and Professor Osamu Kano from the Department of Neurology at Toho University School of Medicine has revealed a critical gap in

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Assessing blood stem cell quality by analyzing cell behavior in real time

Researchers uncover how cellular kinetics, captured over time, can accurately predict the quality of hematopoietic stem cells for regenerative medicine. Peer-Reviewed Publication The Institute of Medical Science, The University of Tokyo image: A new study revealed that cellular kinetics, observable over a period of time rather than in a single snapshot, holds important information about

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Detecting cancer cells in blood: the development of microchannel devices with microcone arrays

Researchers utilize engraved polycarbonate sheets and antibody coatings to efficiently capture cancer cells Peer-Reviewed PublicationChiba University image: By imprinting microcones on polycarbonate sheets followed by coating with human epithelial cell adhesion molecule antibodies, scientists from Japan have developed a microchannel-based diagnostic tool. Their device demonstrated high sensitivity while maintaining a capture efficiency of more than

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