alzheimer

by Ingrid Fadelli, Medical Xpress edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source A) Immunoblot profile of synthetic Aβ preparation containing monomers, dimers, trimers, tetramers and high molecular weight oligomers. B) IF staining of HuC/D, Tuj1 (green) and Aβ (red) in Ctrl and Aβ-treated pure enteric neurons isolated from WT

by PNAS Nexus edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain Amyloid beta and tau proteins compete for the same binding sites on microtubules in neurons, suggesting that displacement of tau by amyloid beta, rather than aggregation of either protein, may be the primary driver of

by Keck School of Medicine of USC edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source The colors show how much tau was detected in different parts of the brain. Blue marks areas with lower levels, while red marks areas with higher levels. Credit: USC/Stevens INI A team of researchers at

When Annie Goettemoeller first started working on Alzheimer’s, many of her colleagues were focused on the buildup of amyloid and tau proteins in and around neurons. The going theory at the time was that targeting those might help slow or even reverse cognitive decline. But Goettemoeller, a Wu Tsai Neurosciences Institute Postdoctoral Scholar supported by the Knight Initiative for Brain Resilience,

by German Center for Neurodegenerative Diseases edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain A certain blood protein regarded as an early indicator of Alzheimer’s disease also appears to play a role in other disorders. Researchers at DZNE and the Hertie Institute for Clinical Brain Research

New study finds aptamers that target neurofilament light chain, a protein released into the blood when neurons are damaged Peer-Reviewed Publication Tokyo University of Science image: Scientists uncover DNA aptamers as promising new tool that can detect neurofilament light chain, a key blood biomarker linked to Alzheimer’s disease and other neurodegenerative disorders. These findings support

by VIB (the Flanders Institute for Biotechnology) edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Fluorescent HiLyte647-labeled Aβ42 confirms the identity of cell-derived fibrillar deposits. Credit: Proceedings of the National Academy of Sciences (2026). DOI: 10.1073/pnas.2516774123 A new study led by researchers from VIB and KU Leuven shows that immune cells called

New findings from Scripps Research show that changes in protein shape—rather than quantity of proteins—offer a potential new way to detect and track Alzheimer’s disease. Peer-Reviewed Publication Scripps Research Institute image: A computer-generated model illustrates a potential complex formed by three blood proteins—ApoE (purple), haptoglobin (cyan), and Serpina3 (red). Researchers found that subtle structural changes

by Cell Press edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Tanycytes in green capturing Tau protein in red. Credit: Vincent Prévot, INSERM Accumulation of the protein tau in the brain is one of the hallmarks of Alzheimer’s disease. In a paper published in Cell Press Blue, researchers report a previously