February 3, 2026

It takes two: Genes ATP13A2 and GBA1 interact to drive neurodegeneration

by Homa Warren, Baylor College of Medicine edited by Gaby Clark, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease, affecting more than 10 million people worldwide. People with this condition may experience tremors, limb stiffness, gait and […]

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Everyday diabetes medicine could treat common cause of blindness

by University of Liverpool edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain Doctors have found that metformin, an everyday medicine for diabetes, is associated with less progression of age-related macular degeneration (AMD), the most common cause of blindness in western countries. In a recent study, people

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Trump policies at odds with emerging understanding of COVID’s long-term harm

by Stephanie Armour edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain Possible risk of autism in children. Dormant cancer cells awakening. Accelerating aging of the brain. Federal officials in May 2023 declared an end to the national COVID pandemic. But more than two years later,

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A new way to communicate with neurons using focused ultrasound stimulation

by Iqra Bano edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Schematic illustration of low-intensity focused ultrasound (FUS) applied to cultured primary cortical neurons and real-time monitoring of intracellular Ca²⁺ activity by fluorescence imaging. FUS activates mechanosensitive pathways and calcium-dependent signaling, leading to regulated neuronal excitability and downstream cellular

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Focused ultrasound for glioblastoma (GBM): Clinical results and follow-on trial in Taiwan

by Focused Ultrasound Foundation edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source FUS target selection and treatment plan establishment. Credit: Neurosurgery (2025). DOI: 10.1227/neu.0000000000003851 Results from a pilot clinical trial evaluating the safety and feasibility of repeated focused ultrasound-induced blood–brain barrier (BBB) opening combined with the monoclonal antibody drug Avastin (bevacizumab)

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Spotting skin cancer sooner with the help of artificial intelligence

What if the earliest signs of skin cancer could be identified sooner — before a dermatology appointment? Kamlendra Singh and Steven Ice. Image credit: University of Missouri Researchers at the University of Missouri are exploring how artificial intelligence could help detect melanoma — the most dangerous form of skin cancer — by evaluating images of suspicious skin

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Emphasizing the strengths of people with depression can help those affected

by University of Vienna edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source The depression-reframing approach: Reframing the implications of depression experiences. Credit: Personality and Social Psychology Bulletin (2026). https://doi.org/10.1177/01461672251412492 People suffering from depression demonstrate strength in dealing with their illness on a daily basis, but this is often not perceived as such.

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RCT demonstrates effectiveness of mylovia, a digital therapy for female sexual dysfunction

Peer-Reviewed PublicationGAIA (Germany) image: After three months of using mylovia in addition to their usual treatment, a statistically significant and clinically relevant improvement in sexual function was observed in the intervention group compared to the control group. view more  Credit: Blaszcyk, W., et al., (2026) Digital intervention mylovia improves sexual functioning in women with sexual dysfunction

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High blood pressure uncontrolled in 4 out of 5 Americans

by Dennis Thompson edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Four out of five American adults with high blood pressure don’t have their condition under control, putting them at increased risk for heart disease and dementia, a new study says. About 79% of people with high blood pressure have failed

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Single-shot HIV vaccine candidate induces neutralizing antibodies for the first time

by The Wistar Institute edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source c, Close-up views highlighting the interactions of the Fabs from NHP 1 and 3 (blue and red) with the Asn160 glycan of WIN332. d, Densities of NHP 1 Fab (green) bound to RC1 (gray) with RC1 model fit

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