hiv vaccine

Single-shot HIV vaccine candidate induces neutralizing antibodies for the first time

by The Wistar Institute edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source c, Close-up views highlighting the interactions of the Fabs from NHP 1 and 3 (blue and red) with the Asn160 glycan of WIN332. d, Densities of NHP 1 Fab (green) bound to RC1 (gray) with RC1 model fit […]

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Combined HIV vaccines can act in concert to achieve diverse antibody priming

by Justin Jackson, Medical Xpress edited by Sadie Harley, reviewed by Robert Egan MPEM after multipriming immunization. A cocktail of N332-GT5 and ApexGT5 was used to form complexes with pooled serum IgG (digested to Fab) from triple mRNA-LNPs (high dose, D) or proteins (5 μg of N332-GT5, 5 μg of ApexGT5, and 10 μg of eOD-GT8, E) primed

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Scientists make progress in the long search for an HIV vaccine

In the decades-long push to develop an HIV vaccine, researchers reported yesterday that they’ve managed to circumvent one particularly stubborn challenge. While developing a messenger RNA-based vaccine, the researchers found that the key was to make it hide a key protein complex that usually pokes out of the surface of the virus, because that complex

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HIV vaccine study uncovers powerful new antibody target

by The Scripps Research Institute edited by Gaby Clark, reviewed by Robert Egan   An electron density map illustrating how the new antibody (purple) neutralizes HIV by binding across two sections of the spike protein (gray). Credit: Scripps Research In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new

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