February 3, 2026

Faced with common heart failure symptoms, most young adults wouldn’t seek care

by Dennis Thompson edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Alex Balmes’ symptoms were uncommon for a 32-year-old—irregular heartbeat, fatigue, shortness of breath, bloating, unexpected weight gain. In fact, these are all classic symptoms of heart failure, but Balmes didn’t give that possibility any thought at all. “I […]

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Use of glucose-lowering SGLT2i drugs may help patients with gout and diabetes take fewer medications

by Mass General Brigham edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Graphical abstract. Credit: Diabetes Care (2026). DOI: 10.2337/dc25-1713 Gout, a type of inflammatory arthritis caused by a buildup of uric acid (urate) in the body, affects 5.1% of U.S. adults (over 12 million), including 10% of those aged 65 or

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Why aren’t more older adults getting flu or COVID-19 shots?

by University of Michigan edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source National Poll on Healthy Aging data from adults age 50 and over who replied to a poll in late December 2025 and early January 2026 saying that they had not received a flu vaccination in the last six

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Computational models predict neural activity for re-establishing connectivity after stroke or injury

by Hong Kong University of Science and Technology edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source The general structure and information flow of RL-based spike generation. Credit: Nature Computational Science (2026). DOI: 10.1038/s43588-025-00915-5 Researchers at The Hong Kong University of Science and Technology (HKUST) School of Engineering have developed a novel reinforcement

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MDGA2 gene malfunction removes brain’s excitatory ‘brake’ to trigger severe epilepsy, study finds

by Daegu Gyeongbuk Institute of Science and Technology edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Graphical abstract. Credit: The American Journal of Human Genetics (2026). DOI: 10.1016/j.ajhg.2025.12.015 The DGIST Center for Synapse Diversity and Specificity has identified MDGA2 as a novel causative gene for developmental and epileptic encephalopathy (DEE), a rare

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Clinical data gaps keeping life-saving antibiotics from children

by Murdoch Children’s Research Institute edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Unsplash/CC0 Public Domain Life-saving antibiotics that could treat severe infections in babies and children aren’t accessible due to a lack of data around safety and dosage, new research shows. Two wide sweeping reviews, led by Murdoch

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Some neurons age early: Aging clock reveals molecules that protect against neurodegeneration

by Anna Euteneuer, University of Cologne edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source The nervous system in the nematode can be made visible by the formation of fluorescent dyes in neurons and observed during the normal aging process of the animals. Credit: Christian Gallrein/University of Cologne Using an aging

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How a common immunosuppressive drug injures liver blood vessels

by Institute of Science Tokyo edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Cell Reports Medicine (2025). DOI: 10.1016/j.xcrm.2025.102433 In a human organoid-based mechanistic investigation, researchers revealed how an immunosuppressive drug, antithymocyte globulin (ATG), induces injury to blood vessels in the liver. According to the study, ATG first triggers rapid clotting

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The peptide with big claims but limited data

You may not have heard of BPC-157 — but maybe you have. The peptide, like many that have gained traction with MAHA, is having a moment. Popular podcasters, wellness clinics, and patients are gravitating to the chemical for relief from health conditions that aren’t always well-managed with traditional treatments. But there’s one problem: “The amount of

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Survey finds 93% of IBD community support predictive testing and prevention strategies

by Crohn’s & Colitis Foundation of America edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain A new Crohn’s & Colitis Foundation–led survey of more than 1,500 people living with or at risk for inflammatory bowel disease (IBD) found that 93% would be interested in a

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