by The Scripps Research Institute edited by Gaby Clark, reviewed by Robert Egan An electron density map illustrating how the new antibody (purple) neutralizes HIV by binding across two sections of the spike protein (gray). Credit: Scripps Research In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new […]
HIV vaccine study uncovers powerful new antibody target Read More »
by University of Copenhagen edited by Gaby Clark, reviewed by Robert Egan Graphical abstract Credit: Cell (2025). DOI: 10.1016/j.cell.2025.05.005 Scientists have unearthed surprising details about how our bodies handle insulin—the hormone that plays a crucial role in regulating blood sugar and developing diabetes. The discovery could lead to better treatment of type 2 diabetes and earlier diagnosis, potentially even
by University of Virginia edited by Gaby Clark, reviewed by Robert Egan Graphical abstract Credit: Med (2025). DOI: 10.1016/j.medj.2025.100747 An inexpensive, long-approved HIV drug can improve vision in patients with a blinding complication of diabetes more effectively and at a much lower cost than many existing treatments, an initial clinical trial suggests. Further, the drug is taken orally, potentially
by Allessandra DiCorato, Broad Institute of MIT and Harvard edited by Gaby Clark, reviewed by Robert Egan Synonymous cytosine base editing of CAG repeats in vitro. Credit: Nature Genetics (2025). DOI: 10.1038/s41588-025-02172-8 Broad Institute researchers have developed a way to edit the genetic sequences at the root of Huntington’s disease and Friedreich’s ataxia. The conditions are two of more
Gene editing disrupts Huntington’s mutation in mice Read More »
by Hannamaija Helander, University of Helsinki edited by Lisa Lock, reviewed by Robert Egan Cumulative hazard of incident chronic disease and mortality in primary analysis. Credit: JAMA Network Open (2025). DOI:10.1001/jamanetworkopen.2025.11825 Losing weight via lifestyle adjustments can deliver significant long-term health benefits, without the need for surgery or anti-obesity drugs. Alongside preventing diabetes, it can help ward off chronic
Midlife weight loss linked to longer, healthier lives Read More »
by BGI Genomics edited by Gaby Clark, reviewed by Robert Egan BGI Genomics study found Gut Bacteria-Producing L-Arginine Boost Bone Health. Credit: BGI Genomics A recent study involving 684 Chinese adults has uncovered a significant connection between gut microbiota, aging, and bone health, particularly in relation to osteoporosis, a condition that weakens bones and increases the risk
Firmicutes gut bacteria boost metabolism and bone health, study finds Read More »
May 27, 2025 The GIST Knee arthritis made worse with steroid injections by Radiological Society of North America edited by Gaby Clark, reviewed by Andrew Zinin Knee MRI scans in a 58-year-old female participant in the Osteoarthritis Initiative who was administered a corticosteroid injection. Sagittal intermediate-weighted images obtained (A) 2 years before injection, (B) at the time of
Knee arthritis made worse with steroid injections Read More »
by King’s College London edited by Lisa Lock, reviewed by Robert Egan Transcriptomic and epigenomic profiling of xenotransplanted microglia reveals changes to their regulation in Alzheimer’s disease across the different APOE isoforms. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-60099-4 A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer’s disease. The study,
by Sharon Theimer, Mayo Clinic edited by Stephanie Baum, reviewed by Andrew Zinin Credit: Pixabay/CC0 Public Domain Globally, women are roughly twice as likely as men to be diagnosed with thyroid cancer. However, recent research shows that men face an equal risk. Mayo Clinic experts say that men and women alike should be aware of thyroid cancer
Understanding the thyroid cancer risks for women and men Read More »
by Inka Burow, Hannover Medical School edited by Stephanie Baum, reviewed by Robert Egan Impact of anti-CD19 CAR-T cells on acquired hemophilia. Credit: Leukemia (2025). DOI: 10.1038/s41375-025-02554-1 Cell and gene therapies harbor great hopes for biomedicine. They are becoming increasingly important for diseases that are currently difficult or impossible to treat—for example, aggressive forms of cancer or rare diseases
CAR-T cell therapy yields success in treating autoimmune hemophilia Read More »
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