May 28, 2025

Combining stem cell engineering and drug therapy to suppress abnormal bone formation

by Kyoto University edited by Lisa Lock, reviewed by Robert Egan   Credit: JBMR Plus (2025). DOI: 10.1093/jbmrpl/ziaf068 A research team led by Associate Professor Makoto Ikeya in the Department of Clinical Application at Kyoto University has developed a promising new therapeutic strategy for fibrodysplasia ossificans progressiva (FOP)—a rare and severely disabling genetic disorder—by combining low-dose rapamycin with mesenchymal stem/stromal […]

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Targeting the epipharynx to disrupt the residual triggers of COVID-19 in patients with long COVID

by Cactus Communications edited by Stephanie Baum, reviewed by Robert Egan   The epipharynx is located posterior to the nasal cavity. The region outlined with dashed lines indicates the epipharynx. Credit: Dr. Kensuke Nishi, Fukuoka Dental College, Japan The COVID-19 pandemic had a profound effect on the world, resulting in a dramatic loss of human lives. While

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Two genes linked to common inflammatory arthritis suggest new treatment options

by Elsevier edited by Gaby Clark, reviewed by Robert Egan   A study in the Annals of the Rheumatic Diseases uncovers new genetic links to calcium pyrophosphate deposition (CPPD) disease, a common type of inflammatory arthritis. This image shows an X-ray revealing chondrocalcinosis (radiographic evidence of CPPD) in the lateral menisci and hyaline cartilage of both knees. Credit: Sara Tedeschi,

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FDA approves topical foam for plaque psoriasis of the scalp and body

by Lori Solomon edited by Sadie Harley, reviewed by Andrew Zinin   The U.S. Food and Drug Administration has approved Arcutis Biotherapeutics’ Zoryve (roflumilast) topical foam 0.3% for the treatment of plaque psoriasis of the scalp and body in adult and pediatric patients 12 years of age and older. Through a supplemental new drug application, Zoryve foam

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Size matters when it comes to antibiotics. Obese patients may need customized doses of certain drugs

by Delthia Ricks, Phys.org edited by Gaby Clark, reviewed by Robert Egan   Physiological changes and their possible impact on antibiotic pharmacokinetics and drug exposure in patients with obesity. Figure created with BioRender.com. Credit: The Lancet Infectious Diseases (2025). DOI: 10.1016/S1473-3099(25)00155-0 Obesity can have a distinct impact on the absorption, effectiveness and excretion of antibiotics, medications that have been in

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Cardiorespiratory effects of wildfire smoke particles can persist for months, even after a fire has ended

by The Mount Sinai Hospital edited by Sadie Harley, reviewed by Andrew Zinin   Credit: Unsplash/CC0 Public Domain Being exposed to lingering fine particulate matter (PM2.5) from wildfire smoke can have health effects for up to three months afterwards, well beyond the couple of days that previous studies have identified, and the exposure can occur even after the

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Guidelines updated as rare skin condition found to raise risk of mood disorders and arrhythmias

by Cardiff University edited by Gaby Clark, reviewed by Andrew Zinin   Credit: Unsplash/CC0 Public Domain International guidelines for the screening of a rare skin condition have changed after scientists found an elevated rate of psychological disorders and heart issues. Cardiff University researchers have shown that the rare skin condition, X-linked ichthyosis—which is caused by a genetic deletion, is

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Experts explain how to strengthen your pelvic floor

by University of Rochester Medical Center edited by Gaby Clark, reviewed by Andrew Zinin   Credit: CC0 Public Domain Pelvic floor health is crucial for overall well-being but is often overlooked. Ryenn Sanger, NP and Marc Eigg, MD, experts in pelvic conditions at the University of Rochester Medical Center, explain how to strengthen pelvic floor muscles and what

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Q&A: What is normal pressure hydrocephalus, the condition Billy Joel just revealed?

by Jane Kelly, University of Virginia edited by Sadie Harley, reviewed by Andrew Zinin   Credit: CC0 Public Domain Musician Billy Joel recently canceled his concert tour, announcing he will undergo physical therapy for a condition called normal pressure hydrocephalus that is affecting his hearing, vision and balance. UVA Health’s Neurology Department recently opened a clinic to treat

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How diet can help prevent muscle injuries in the over 50s

by Patricia Yárnoz Esquíroz, The Conversation edited by Sadie Harley, reviewed by Andrew Zinin   Credit: Pixabay/CC0 Public Domain More and more people over the age of 50 are taking up physical exercise. Medical associations resoundingly agree that this is a good thing. Physical exercise is not only key to disease prevention, it is also a recommended part of treatment

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