depression

by Université catholique de Louvain edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Credit: Pixabay/CC0 Public Domain An international research team has uncovered a surprising ally in the fight against insulin resistance and type 2 diabetes: a microbial metabolite called trimethylamine (TMA). Published in Nature Metabolism, the study reveals that TMA, produced by gut bacteria from dietary choline, can

by Marianne Lie Becker, University of Southern Denmark edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Credit: Unsplash/CC0 Public Domain Gynecological disorders such as endometriosis, PCOS, and menstrual irregularities are common and often associated with pain and disruption to everyday life. They are typically diagnosed late, and many women experience both physical discomfort and mental distress

by Dennis Thompson edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes People with depression have a more than doubled risk of developing epilepsy, a new study says. Worse, depression then makes epilepsy more difficult to treat, according to results of a second study. Both papers, presented at the annual meeting in Atlanta of the American Epilepsy

by University of Birmingham edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Credit: Unsplash/CC0 Public Domain Patients with major depressive disorder, including those who have not responded to first-line antidepressants, may benefit from short-term nitrous oxide treatment, a major meta-analysis led by the University of Birmingham has found. The paper published in eBioMedicine has assessed the best available

by The Korea Advanced Institute of Science and Technology (KAIST) edited by Sadie Harley, reviewed by Robert Egan Integration of clinical symptoms, blood analysis, and patient-derived brain organoid analysis in women with major depressive disorder. Credit: Advanced Science (2025). DOI: 10.1002/advs.202508383 Major depressive disorder (MDD) is characterized by a lowered mood and loss of interest, contributing not only to difficulties

By Malcolm Azania November 17, 2025 Facebook Twitter LinkedIn Reddit Flipboard Email There could be new hope for people suffering from treatment-resistant depression Depositphotos View 2 Images Despite the advice of two of the most successful pop anthems of the last two decades, when it comes to depression, no one can just “shake it off” or

by Justin Jackson, Medical Xpress edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Credit: Unsplash/CC0 Public Domain University of Auckland researchers report that an 8-week, twice-weekly LSD microdosing regimen for major depressive disorder was feasible and well-tolerated, with Montgomery-Åsberg Depression Rating Scale (MADRS) scores reduced by 59.5% at the end of treatment and sustained to six