November 20, 2025

AI psychosis risk: LLMs fail to challenge delusions, experts warn

November 20, 2025 / Artificial Intelligence, Clinical Practice / InnovateMed Author / AI psychosis risk, LLMs

by JMIR Publications edited by Gaby Clark, reviewed by Andrew Zinin Editors’ notes Credit: Ivan S from Pexels An article, “Shoggoths, Sycophancy, Psychosis, Oh My: Rethinking Large Language Model Use and Safety,” explores how features like AI sycophancy may amplify delusional beliefs and contribute to user harm, a phenomenon often referred to as “AI psychosis.” The paper […]

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New on-switch for pain signaling pathway could lead to safer treatment and relief

November 20, 2025 / Pain Management, Research update / InnovateMed Author / pain signaling pathway

by Tulane University edited by Lisa Lock, reviewed by Robert Egan Editors’ notes Credit: Public Domain Researchers at Tulane University, with a team of colleagues from eight other universities, have discovered a new nerve cell signaling mechanism that could transform our understanding of pain and lead to safer, more effective treatments. The study, co-led by Matthew Dalva, director

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New Device May Reduce Hospitalizations of Children With Severe Asthma Attacks

November 20, 2025 / Research update / InnovateMed Author / asthma, Severe Asthma Attacks

Lara Salahi November 10, 2025 A new bronchodilator delivery device, SOBIstat-F, reduced hospitalization rates and improved clinical outcomes in children with severe acute asthma, according to a randomized clinical trial presented at the European Academy of Paediatrics (EAP) 2025. The study, conducted in two pediatric emergency departments in Asunción, Paraguay, involved 84 pediatric patients treated for

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A new strategy for treating atrial fibrillation: Targeting the TRPC3 channel

November 20, 2025 / Research update / InnovateMed Author / atrial fibrillation

Peer-Reviewed Publication Toho University image: An aorto-venocaval shunt (AVS) produces chronic volume overload for ≥12 weeks, leading to the formation of arrhythmogenic substrates in the rat atria, and the TRPC3 inhibitor pyrazole-3 (Pyr3) effectively suppresses sustained atrial fibrillation. ECG: electrocardiogram, RA: right atrial electrocardiogram, BP: blood pressure view more Credit: Dr. Akira Takahara A research group

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Daily oral GLP-1 pill exhibits promising results in treatment options for adults with diabetes and obesity in trial led by UTHealth Houston researcher

November 20, 2025 / Diabetes, Research update / InnovateMed Author / obesity, oral GLP-1

Peer-Reviewed Publication University of Texas Health Science Center at Houston A new oral GLP-1 medication can help adults with obesity and Type 2 diabetes lose more weight and improve their blood sugar levels compared to a placebo, according to findings from the ATTAIN-2 trial led by a UTHealth Houston researcher. Obesity is a chronic health

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The therapeutic target against memory impairments in Down syndrome gains strength

November 20, 2025 / Research update / InnovateMed Author / down syndrome

The experimental, long-term pharmacological treatment in a mouse model for Down syndrome to reduce the activity of CB1 improves the memory defects associated with the syndrome even when age-related neurodegeneration is added. Peer-Reviewed Publication Universitat Pompeu Fabra – Barcelona image: Detail of the hippocampus of control subjects (left) and with Down syndrome (right) where the

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New conductive hydrogel is as soft as the brain

November 20, 2025 / Research update / InnovateMed Author / hydrogel

Peer-Reviewed Publication University of Groningen image: This is associate professor Ranjita Bose, who lead the team which created a biocompatible conductive polymer hydrogel, which can be used in a range of applications view more Credit: University of Groningen Bioelectronics, such as implantable health monitors or devices that stimulate brain cells, are not as soft as the

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Inflammatory biomarkers in ischemic stroke: mechanisms, clinical applications, and future directions

November 20, 2025 / Research update / InnovateMed Author / Inflammatory biomarkers, ischemic stroke

Peer-Reviewed Publication Xia & He Publishing Inc. image: Cellular death within the infarcted core occurs rapidly due to energy depletion, resulting in the release of DAMPs such as HMGB1, ATP, and HSPs. These DAMPs engage pattern recognition receptors, including Toll-like receptors (TLR2 and TLR4) and scavenger receptors, thereby initiating innate immune responses. For instance, the

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Aged blood vessel cells drive metabolic diseases

November 20, 2025 / Research update / InnovateMed Author / Aged blood vessel, metabolic diseases

Cedars-Sinai preclinical study lays foundation for future development of treatments for complex diseases like diabetes Peer-Reviewed Publication Cedars-Sinai Medical Center Investigators from the Center for Advanced Gerotherapeutics at Cedars-Sinai found that aged blood vessel cells play a key role in the development of metabolic disorders, including diabetes. The preclinical findings, published in Cell Metabolism, could lead

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