down syndrome

by University of Colorado Anschutz edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Cell Reports (2026). DOI: 10.1016/j.celrep.2025.116835 Researchers at the University of Colorado Anschutz Linda Crnic Institute for Down Syndrome (Crnic Institute) have uncovered compelling evidence that individuals with Down syndrome experience significant alterations in liver metabolism, including elevated levels […]

The experimental, long-term pharmacological treatment in a mouse model for Down syndrome to reduce the activity of CB1 improves the memory defects associated with the syndrome even when age-related neurodegeneration is added. Peer-Reviewed Publication Universitat Pompeu Fabra – Barcelona image: Detail of the hippocampus of control subjects (left) and with Down syndrome (right) where the

After decades of mystery, Gladstone researchers identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice. Peer-Reviewed Publication Gladstone Institutes image: After decades of mystery, researchers at Gladstone Institutes identify a gene that can derail heart formation—and show that fixing it prevents the problem in mice. view more   Credit:

by Traci Hale, University of Virginia edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Graphical abstract. Credit: Cell Reports (2025). DOI: 10.1016/j.celrep.2025.116300 New research suggests a missing brain molecule may hold the key to understanding—and potentially treating—the faulty neural circuits seen in Down syndrome. Restoring the molecule, called pleiotrophin, could enhance brain function in people with Down syndrome

by Maria Fernanda Ziegler, FAPESP edited by Robert Egan  Editors’ notes Inflammation mapped in the brains of people with and without Down syndrome in different age groups. Credit: Daniele de Paula Faria Down syndrome is associated with accelerated aging. It is estimated that up to 90% of individuals with the condition develop Alzheimer’s disease before the age