August 15, 2025

PD-1 + IL-2 power couple: Wake up ‘sleepy’ T cells to turbo-charge cancer cures

August 15, 2025 / Research update / InnovateMed Author / cancer

New bifunctional molecules merge checkpoint blockade with precision IL-2 delivery, cutting toxicity and lifting cure rates in early trials Peer-Reviewed Publication Science China Press image: PD-1/IL-2 bifunctional molecules block PD-1i mmunosuppressive signals while cis-activating T cells. view moreCredit: ©Science China Press Researchers at Peking Union Medical College Hospital have mapped out why pairing two well-known cancer […]

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Using bacteria to sneak viruses into tumors

August 15, 2025 / Research update / InnovateMed Author / tumors

The bioengineered platform enables a cancer-killing virus to evade the patient’s immune system — and prevents it from spreading throughout the body. Peer-Reviewed Publication Columbia University School of Engineering and Applied Science image: In this microscopic image, grey indicates small cell lung cancer cells, magenta shows Salmonella that have entered the cancer cells, and cyan

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The future is now

August 15, 2025 / News update / InnovateMed Author / future

Scientists can now use a computer to decode your inner speech. Yes, you read that correctly: a person unable to express themselves through words was able to speak to others using only their internal monologue (and millions of dollars of electronics and an implant in their head), according to a study published Thursday. The study could

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Does This Side Effect Spell Doom for the GLP-1’s?

August 15, 2025 / Research update / InnovateMed Author / GLP 1

This transcript has been edited for clarity. Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. About a year ago, I was talking to one of my friends about the slew of studies showing very broad benefits of the GLP-1 receptor

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AI voice test could help spot dangerous throat lesions before symptoms appear

August 15, 2025 / Research update / InnovateMed Author / throat lesions

By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Lauren HardakerAug 14 2025 By measuring subtle changes in voice quality, AI could help doctors detect dangerous vocal fold lesions before symptoms worsen. Study: Voice as a biomarker: exploratory analysis for benign and malignant vocal fold lesions. Image Credit: 3dMediSphere / Shutterstock An exploratory study reveals that subtle changes in voice patterns, especially

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GIPR signaling opens brain’s gate for GLP-1 weight-loss therapy

August 15, 2025 / Research update / InnovateMed Author / Weight loss

By Vijay Kumar MalesuReviewed by Susha Cheriyedath, M.Sc.Aug 14 2025 A new study uncovers how GIPR signaling in brain cells helps GLP-1 weight-loss drugs bypass the blood-brain barrier and amplify their appetite-suppressing effects, offering a mechanistic explanation for the clinical power of co-agonists. Study: Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism.

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Ultrasensitive platform detects Alzheimer’s biomarkers in body fluids with high precision

August 15, 2025 / Research update / InnovateMed Author / alzheimer

by National Research Council of Science and Technology edited by Sadie Harley, reviewed by Robert Egan Schematic illustration of the KRISS-developed SERS-based ultrasensitive multiplexed quantitative sensing platform. Credit: Korea Research Institute of Standards and Science (KRISS) The Korea Research Institute of Standards and Science (KRISS) has developed a diagnostic platform that amplifies the unique optical signals of molecules

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Dietary patterns linked to chronic kidney disease risk

August 15, 2025 / Research update / InnovateMed Author / CKD

by Elana Gotkine edited by Stephanie Baum, reviewed by Robert Egan Compared with other dietary indices, Dietary Approaches to Stop Hypertension (DASH) and the Dietary Inflammatory Index (DII) provide chronic kidney disease (CKD) risk discrimination, according to a study published online Aug. 5 in Renal Failure. Xianglong Meng, from the University of Electronic Science and Technology of China in Chengdu,

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Lupus low disease activity state attainable in lupus nephritis

August 15, 2025 / Research update / InnovateMed Author / lupus nephritis

by Elana Gotkine edited by Stephanie Baum, reviewed by Robert Egan In lupus nephritis, attainment of complete renal response (CRR)/partial renal response (PRR) and lupus low disease activity state (LLDAS) is associated with best relapse-free survival, with independent associations seen with lupus nephritis relapse risk reduction, according to a study published online July 20 in Arthritis Care & Research. Chak

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Experts recommend SGLT-2 and GLP-1 only for adults at moderate to high risk of heart and kidney problems

August 15, 2025 / Clinical Practice / InnovateMed Author / GLP1

by British Medical Journal edited by Sadie Harley, reviewed by Robert Egan Credit: Unsplash/CC0 Public Domain SGLT-2 inhibitor and GLP-1 receptor agonist drugs should be used in all or almost all adults with type 2 diabetes at higher risk of cardiovascular and kidney complications, and in the majority of adults at moderate risk of complications, says a

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