systemic sclerosis

Universal stem cells reset immunity in a systemic sclerosis patient

July 9, 2025 / Research update / InnovateMed Author / systemic sclerosis

by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan Graphical abstract. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.05.038 Research led by Naval Medical University’s Changzheng Hospital in China reports that an off-the-shelf cell therapy built from induced pluripotent stem cells (iPSCs) loosened life-limiting skin and organ scarring in a woman with systemic sclerosis. Systemic sclerosis progressively suffocates tissue […]

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Specific immune cells linked to severe organ damage in systemic sclerosis

June 17, 2025 / Immunology, Research update / InnovateMed Author / immune cells, systemic sclerosis

by The University of Osaka edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Patients with scleroderma renal crisis demonstrated specific enrichment of CD14+ monocytes with increased EGR1 expression and activation of NF-κB–related pathways. Trajectory analysis indicated that they differentiated into macrophages and expressed high levels of THBS1 in the kidney. In patients with SSc-ILD, CD8+ effector

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Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

June 17, 2025 / Genetics, Integrative exome sequencing, Research update / InnovateMed Author / machine learning, systemic sclerosis

by Molly Chiu, Baylor College of Medicine edited by Robert Egan Editors’ notes Graphical abstract. Credit: Annals of the Rheumatic Diseases (2025). DOI: 10.1016/j.ard.2025.05.009 Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been identified, but others remain unknown, which has impeded the development of targeted treatments. In a new study published in Annals

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Universal stem cells reset immunity in a systemic sclerosis patient

Specific immune cells linked to severe organ damage in systemic sclerosis

Integrative exome sequencing and machine learning identify new genes contributing to systemic sclerosis risk

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