immune cells

Johns Hopkins Scientists Engineer Nanoparticles Able to Seek and Destroy Diseased Immune Cells

Proof of principle study in mice uses emerging technology mRNA-based therapies  The Johns Hopkins-developed nanoparticles were able to induce the destruction of the majority of the immune system cells called B cells, which contribute to diseases such as lupus and cancers of the blood. Top image: Blue dyed B cells in the spleen of an […]

Johns Hopkins Scientists Engineer Nanoparticles Able to Seek and Destroy Diseased Immune Cells Read More »

A universal ‘instruction manual’ helps immune cells protect our organs

by University de Liege edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Macrophages with MafB (WT) look mature and well-shaped, while those without MafB (KO) appear round and less developed. Credit: University of Liège / Philippe Compère Researchers at the University of Liège have identified a key genetic regulator that

A universal ‘instruction manual’ helps immune cells protect our organs Read More »

Mint, eucalyptus and chili compounds reveal powerful synergy against inflammation in immune cells

by Tokyo University of Science edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Unsplash/CC0 Public Domain Many everyday foods and seasonings—such as herbs, spices, and aromatic plants—contain natural compounds called phytochemicals that can regulate inflammatory pathways. For centuries, these ingredients have been used together in traditional cuisine and herbal

Mint, eucalyptus and chili compounds reveal powerful synergy against inflammation in immune cells Read More »

How your life story leaves epigenetic fingerprints on your immune cells

by Salk Institute edited by Stephanie Baum, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Overview of the study. For HIV-1 and IAV, we have internal control samples that are from the same set of donors before infection and collected samples from them after exposure. We also collected PBMC from 12 healthy donors as

How your life story leaves epigenetic fingerprints on your immune cells Read More »

A ‘recipe book’ for reprogramming cells into disease-fighting immune cells

by Lund University edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Graphical abstract. Credit: Cell Systems (2026). DOI: 10.1016/j.cels.2025.101457 In order to reprogram readily available cells into specific immune cells that fight various diseases, one must know the “recipe” for the transformation. Researchers at Lund University have now created a library of

A ‘recipe book’ for reprogramming cells into disease-fighting immune cells Read More »

Immune cells in the brain help shape adolescent neural circuits

by University of Rochester Medical Center edited by Robert Egan Adolescent wheel running promotes DA bouton formation and microglial process outgrowth. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-63314-4 Making a smoothie, going for an evening walk, or having empathy for a loved one are all examples of executive functions that are controlled by the brain’s frontal cortex. This area of

Immune cells in the brain help shape adolescent neural circuits Read More »

Molecular timeline provides insights into how immune cells switch into attack mode

by CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences edited by Sadie Harley, reviewed by Robert Egan   Computer visualization of a macrophage with its characteristic protrusions used to sense its environment, to “crawl”, and to engage pathogens. Credit: (c) CeMM Fighting off pathogens is a tour de force that must happen with speed

Molecular timeline provides insights into how immune cells switch into attack mode Read More »

AI Outperforms People in Scoring Melanoma Tumor-Infiltrating Immune Cells

New research from Yale confirms that artificial intelligence (AI)-based scoring of melanoma tumor-infiltrating immune cells called lymphocytes significantly outperforms traditional pathologist eyeballing. The study, published in JAMA Network Open, found open-source AI tools offered a more standardized and reproducible method for assessment, underscoring the potential for AI to enhance clinical pathology workflows.   A new Yale study found that

AI Outperforms People in Scoring Melanoma Tumor-Infiltrating Immune Cells Read More »

Protecting immune cells from exhaustion

INRS research team makes a promising breakthrough in the fight against chronic infections Peer-Reviewed Publication Institut national de la recherche scientifique – INRS image: Simona Stäger, INRS professor and senior author of the study, expert in immunology of infectious diseases, and Vice-director of Infectiopole. She is also a member of the Pasteur Network. view moreCredit: INRS

Protecting immune cells from exhaustion Read More »

Specific immune cells linked to severe organ damage in systemic sclerosis

by The University of Osaka edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Patients with scleroderma renal crisis demonstrated specific enrichment of CD14+ monocytes with increased EGR1 expression and activation of NF-κB–related pathways. Trajectory analysis indicated that they differentiated into macrophages and expressed high levels of THBS1 in the kidney. In patients with SSc-ILD, CD8+ effector

Specific immune cells linked to severe organ damage in systemic sclerosis Read More »

Scroll to Top