stem cell

Overlooked brainstem pathway that controls human hands offers stroke therapy targets

by Jules Bernstein, University of California – Riverside edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Organization of medullary and C3–C4 propriospinal systems underlying forelimb movement control in mice and humans. (A) Summary of cortical-medullary connectivity, particularly with Lat-RM and CauM, in forelimb movement control in mice. (B) Schematic representation […]

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Giving stem cells room to breathe

Nanogel integrated spheroids increase cell retention and repair injured swallowing muscles Peer-Reviewed Publication Kyoto University image: Hybrid stem cell spheroids containing biodegradable nanogel microfibers improve oxygen diffusion and enhance muscle regeneration in a rat swallowing injury model. view more  Credit: KyotoU / Hideaki Okuyama Kyoto, Japan — Swallowing is a fundamental human function that supports nutrition

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Stem cell expert Q&A: Innovative pathways in biomedical research

by Cedars-Sinai Medical Center edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Clive Svendsen, Ph.D., with an organ-chip that replicates conditions cells would experience in an actual organ and is one of several new research methodologies. Credit: Cedars-Sinai Medical Center New scientific methods could one day render animal studies—the standard

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Stem cell engineering progress paves way for next-generation living drugs

UBC research associate Dr. Ross Jones in the lab where they are working to develop cell-based therapies from stem cells. Credit: Phillip Chin. For the first time, researchers at the University of British Columbia have demonstrated how to reliably produce an important type of human immune cell—known as helper T cells—from stem cells in a

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Researchers identify 166 human pluripotent stem cell lines available for use in clinical applications

by International Society for Stem Cell Research edited by Sadie Harley, reviewed by Robert Egan Melissa Carpenter presents findings from the paper, Pluripotent Stem Cell Lines Available for Use in Clinical Applications: A Comprehensive Overview, at the ISSCR International Symposium in Boston, 11-12 December 2025. Credit: ISSCR To date, more than 100 clinical trials with human pluripotent stem

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Zapping stem cells could boost growth of new tissues and organs

Peer-Reviewed Publication RMIT University image: Dr Kaiwen Zhang and Dr Peter Sherrell (left to right) with the team’s smart electrical stimulus platform, which enables the team to study how stem cells respond to different types electric signals. view more   Credit: Will Wright, RMIT University Scientists in Melbourne have discovered how tiny electrical pulses can steer stem cells as

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Type 1 diabetes cured in mice with gentle blood stem-cell and pancreatic islet transplant

Type 1 diabetes cured in mice with gentle blood stem-cell and pancreatic islet transplant by Krista Conger, Stanford University Medical Center edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Graphical abstract. Credit: Journal of Clinical Investigation (2025). DOI: 10.1172/jci190034 A combination of blood stem cell and pancreatic islet cell transplant from an immunologically mismatched donor completely prevented or

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Scientists use stem cells to move closer to large-scale manufacturing of platelets

Peer-Reviewed Publication International Society for Stem Cell Research Platelets are small, disc-shaped cell fragments in the blood that are essential to stop bleeding and to initiate blood clotting after injury. Platelet transfusions in patients with severe trauma or medical conditions, including bone marrow disease, leukemia, or sepsis, can be lifesaving. Despite being a standard clinical

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Stem cell discovery could be key to tough-to-fix fractures

by Perelman School of Medicine at the University of Pennsylvania edited by Robert Egan Prg4 expression labels a subset of FAPs in skeletal muscle. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2417806122 When bones break and there is extreme tissue loss—such as after a car accident or a battlefield injury—current treatments don’t often lead to effective

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When stem cells feel the squeeze, they start building bone

Research finds that physical forces alone, without chemical cues, can set stem cells on the path to becoming bone cells, opening up new possibilities for regenerative therapies. Peer-Reviewed Publication National University of Singapore College of Design and Engineering FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: Asst Prof Andrew Holle (right) and PhD student Gao Xu (left), first author of the

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