pain

Suppressing postoperative inflammation may prolong pain

by Michigan State University edited by Robert Egan  Editors’ notes Geoffroy Laumet, MSU Associate Professor of Physiology, and Sabrina De Souza, MSU postdoctoral researcher, pipette samples in Laumet’s lab. Credit: Finn Gomez Taking anti-inflammatory drugs after surgery is fairly standard protocol. But a new study from researchers at Michigan State University suggests this approach may be backfiring […]

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Researchers patent formula to block the transition from acute to chronic pain

by University of California, Irvine edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Graphical abstract. Credit: Cell Reports (2025). DOI: 10.1016/j.celrep.2025.116261 Anyone who has experienced chronic pain knows how debilitating it can be. Just ask Daniele Piomelli, Ph.D., who has dealt with pain twice in his life: once after a minor surgery, and again with a bad bout

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New research uncovers link between perfectionism and pain

by Murdoch University edited by Lisa Lock, reviewed by Andrew Zinin Credit: Unsplash/CC0 Public Domain A little self-compassion can go a long way when you have chronic pain, according to a new study out of Murdoch University. The research found that psychological factors may play a crucial role in the experience and management of chronic pain. The study, “Perfectionism, self-compassion,

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How the curves in your spine could be causing you pain

by Dan Baumgardt, The Conversation edited by Gaby Clark, reviewed by Andrew Zinin Credit: Unsplash/CC0 Public Domain Over 60% of us will suffer from lower back pain at some point in our lives. Without question, it’s the leading cause of disability across the globe. Your spine is comprised of 33 bones known as vertebrae, which are stacked one on top of the other. The

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How cloves might help relieve pain and inflammation

by Dipa Kamdar, The Conversation edited by Gaby Clark, reviewed by Andrew Zinin  Credit: Pixabay/CC0 Public Domain Cloves have long been a staple in kitchens and traditional medicine cabinets. Known for their warm, spicy flavor, they’re typically found whole or ground, and as clove oil or extract. But beyond their culinary charm, cloves are gaining scientific attention from researchers and clinicians for

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A new genetic link to pain provides a promising drug target

by University of Oxford edited by Gaby Clark, reviewed by Robert Egan   Cryo-EM processing workflow of SLC45A4 in LMNG, including local and global resolution estimates. Credit: Nature (2025). DOI: 10.1038/s41586-025-09326-y Chronic pain is life-changing and considered one of the leading causes of disability worldwide, making daily life difficult for millions of people around the world, and exacerbating personal and

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How weather changes cause migraines. A neurologist explains the triggers and what you can do to ease the pain

by Danielle Wilhour, The Conversation edited by Lisa Lock, reviewed by Andrew Zinin Credit: Pixabay/CC0 Public Domain If you are one of the 39 million Americans in the U.S. living with migraines, there’s a good chance an intense headache will begin when the weather shifts. You aren’t alone. Studies find 30% to 50% of people with migraines identify some type of weather

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From injury to agony: Scientists discover brain pathway that turns pain into suffering

by Salk Institute edited by Stephanie Baum, reviewed by Andrew Zinin CGRP-expressing neurons (green) in the parvocellular subparafascicular nucleus (SPFp) of the thalamus. Credit: Salk Institute Pain isn’t just a physical sensation—it also carries emotional weight. That distress, anguish, and anxiety can turn a fleeting injury into long-term suffering. Researchers at the Salk Institute have now identified

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More pain, more recovery? In the brain, maybe yes

Triggering a patient’s OCD symptoms or their nicotine cravings right before they receive brain simulation therapy could potentially help make that therapy more effective, according to a study published last week in Jama Psychiatry. Backing up, briefly: Repetitive transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation treatment that, in basic terms, uses coils placed against

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