metabolic disease

Ultrasound detects abdominal fat linked to metabolic diseases

by University of Rovira i Virgili edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain The distribution of body fat, and particularly fat accumulated around the abdomen, is a determining factor in the risk of developing metabolic and cardiovascular diseases. However, not all abdominal fat has the […]

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Cholesterol buildup in liver fat droplets directly drives fibrosis in metabolic disease, study finds

by Jordan Shaked, Yale University edited by Lisa Lock, reviewed by Robert Egan Packing defects on the lipid droplet surface under phosphatidylcholine (PC) deficiency compared to phosphatidylethanolamine (PE). Accumulation of free cholesterol on the surface of hepatic lipid droplets under PC deficiency may contribute to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis

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Key mechanisms of enzyme involved in rare metabolic disease identified

by CIC bioGUNE edited by Gaby Clark, reviewed by Robert Egan 3D-Structure of HsCBS. (Top) Schematic representation of the HsCBS domain organization. The heme-binding site is shown in red, the catalytic core (resembling the PLP-fold type II family) is highlighted in yellow, and the Bateman module is depicted in blue. (Middle) HsCBS monomer in its basal (left)

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Tracking microbial rhythms reveals new target for treating metabolic diseases

Researchers harness the benefits of time-restricted feeding on the gut microbiome, with the ultimate goal of developing new therapies for obesity, diabetes, and related diseases Peer-Reviewed Publication University of California – San Diego image: Researchers used metatranscriptomics to measure the daily rhythms of gut bacteria to better understand the metabolic benefits of time-restricted feeding. view more

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