fibrosis

Heart and metabolic risk factors more strongly linked to liver fibrosis in women than men, study finds

Researchers from the Keck School of Medicine of USC studied sex differences in type 2 diabetes, waist circumference and other risk factors for liver fibrosis in a nationally representative sample Peer-Reviewed Publication Keck School of Medicine of USC Women with certain cardiometabolic risk factors, including type 2 diabetes and high waist circumference, face a greater […]

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New drug candidate reverses metabolic liver disease and fibrosis, pre-clinical data show

by McMaster University edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Graphical abstract. Credit: Cell Metabolism (2026). DOI: 10.1016/j.cmet.2025.11.015 Researchers at McMaster University are leading preclinical studies into a novel drug candidate developed by Espervita Therapeutics that has the potential to prevent and reverse liver fibrosis—a dangerous, disease-induced build-up of scar tissue

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Cholesterol buildup in liver fat droplets directly drives fibrosis in metabolic disease, study finds

by Jordan Shaked, Yale University edited by Lisa Lock, reviewed by Robert Egan Packing defects on the lipid droplet surface under phosphatidylcholine (PC) deficiency compared to phosphatidylethanolamine (PE). Accumulation of free cholesterol on the surface of hepatic lipid droplets under PC deficiency may contribute to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis

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