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Annual Alzheimer’s clinical trials pipeline report shows increased reason for optimism

by University of Nevada, Las Vegas edited by Sadie Harley, reviewed by Andrew Zinin   Credit: Pixabay/CC0 Public Domain An annual review of clinical trials for Alzheimer’s disease highlights a growing number of active trials—and drugs—in the development pipeline and offers optimism for the global effort to find a cure. The annual Alzheimer’s disease drug development pipeline report is led […]

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Immune system discovery reveals potential solution to Alzheimer’s

Peer-Reviewed PublicationUniversity of Virginia Health System FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail image: “Our findings demonstrate that the DNA damage that naturally accumulates during aging triggers STING-mediated brain inflammation and neuronal damage in Alzheimer’s disease,” said researcher John Lukens, PhD, director of UVA’s Harrison Family Translational Research Center in Alzheimer’s and Neurodegenerative Diseases. “These results help to explain why aging

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Lower ‘bad’ cholesterol and higher fat-transport markers linked to less Alzheimer’s risk

by University of Texas Health Science Center at San Antonio edited by Andrew Zinin   Credit: Luan Rezende from Pexels People who are at higher risk for heart disease also seem more likely to develop dementia. And research led by The University of Texas Health Science Center at San Antonio (UT Health San Antonio) has discovered new

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Different versions of APOE protein have varying effects on microglia in Alzheimer’s disease

by King’s College London edited by Lisa Lock, reviewed by Robert Egan   Transcriptomic and epigenomic profiling of xenotransplanted microglia reveals changes to their regulation in Alzheimer’s disease across the different APOE isoforms. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-60099-4 A new study, published today in Nature Communications, offers clues into how APOE isoforms differentially affect human microglia function in Alzheimer’s disease. The study,

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