ALS

by Brian Consiglio, University of Missouri edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source TLN treatment sustains cholinergic synaptic inputs and mitochondria functionality in vivo. Credit: Advanced Science (2026). DOI: 10.1002/advs.202514128 A researcher at the University of Missouri has made a promising breakthrough in the quest to help people with amyotrophic lateral […]

by Dennis Thompson edited by Sadie Harley, reviewed by Alexander Pol  Editors’ notes  The GIST Add as preferred source Early birds and active folks are less likely to develop the degenerative brain disease called amyotrophic lateral sclerosis (ALS), a new study says. People who are early birds had a 20% lower risk of ALS—also known as Lou

by Ann Kellett, Texas A&M University edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Theiler’s murine encephalomyelitis virus mRNA expression in the lumbar spinal cord varied by strain but was absent in all strains by 14 dpi. Credit: Journal of Neuropathology & Experimental Neurology (2025). DOI: 10.1093/jnen/nlaf127 A large, multidisciplinary team led by

by Roni Dengler, Thomas Jefferson University edited by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: American Journal of Physiology-Cell Physiology (2025). DOI: 10.1152/ajpcell.00238.2025 Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no cure and limited treatment options. One of the earliest signs of ALS is overactive brain signals known as cortical hyperexcitability. This

by Karolinska Institutet edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Unsplash/CC0 Public Domain Prolonged exposure to air pollution can be linked to an elevated risk for serious neurodegenerative diseases like ALS and seems to speed up the pathological process, report researchers from Karolinska Institutet in Sweden. The study

by University of Utah edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source RNA-seq revealed a transcriptional signature of inhibition of apoptosis and immune responses by STAU1 KD in HEK293 cells. A Volcano plot with highlighted DEGs. B Modified gene sets identified by GSEA-Hallmark pathway analysis. C Top 10 IPA canonical pathways ranked by p-value. D IPA canonical pathways with

Long-term use of tofersen slows ALS disease progression in people with a genetic subtype, provides hope for treating other forms of ALS by Julia Evangelou Strait•December 22, 2025 Huy Mach Rickey Malloy (left), who receives tofersen treatment for SOD1-ALS at WashU Medicine, plays a round of golf with his wife, Jenny, and their son, Kash. Long-term

by Noah Fromson, University of Michigan edited by Robert Egan  Editors’ notes Study design overview. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-64622-5 Using machine learning models, researchers at Michigan Medicine have identified a potential way to diagnose amyotrophic lateral sclerosis, or ALS, earlier from a blood sample, a study suggests. The models, which analyze blood for biomarkers through gene expression

by Nathan Collins, Stanford University edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes From left: Aaron Gitler, Tetsuya Akiyama, Yi Zeng, Chang Liu, Anastasiia Lovchykova, Stephanie Rayner, Caiwei Guo, Odilia Sianto. Credit: Stanford University The two neurodegenerative diseases could not appear more different. Amyotrophic lateral sclerosis (ALS), sometimes called Lou Gehrig’s disease, affects the muscles, ultimately