ALS

by Northwestern University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Side-by-side image shows control neurons from the study (left) compared to neurons from the study with the mis-spliced KCNQ2 gene. Credit: Northwestern University A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives […]

New research shows: Combining sNfL and cTnT allows more accurate differentiation between ALS and other neurodegenerative diseases Peer-Reviewed Publication Universitatsklinikum Bonn image: UKB research team led by Dr. Patrick Weydt, Paula Lindenborn, and Sarah Bernsen discovers: combination of two blood biomarkers improves diagnostic accuracy in ALS. view more   Credit: University Hospital Bonn / A. Winkler Bonn,

by New York University edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Heat maps showing the geographic patterns of ALS and MS in the US. Credit: Melissa Schilling. Figure based on data from the US CDC Wonder database. A new study published in Scientific Reports indicates that amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) have an extremely high geographic

by Dennis Thompson edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Concussions and traumatic brain injuries (TBI) have been considered a potential cause of ALS, also known as Lou Gehrig’s disease. But a new study argues the association might be the other way around, with concussions providing an early warning sign among folks already in

The blood test, with more than 98% accuracy, opens new avenues for early diagnosis, improved patient care and potential treatment of the neurodegenerative disease Peer-Reviewed Publication Johns Hopkins Medicine By 2040, experts estimate that nearly 400,000 people worldwide will be living with amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease. This degenerative nervous system disease

by Columbia University Irving Medical Center edited by Lisa Lock, reviewed by Robert Egan ISL1 and LHX3 reexpression drive motor neuron subtype-specific changes in gene expression. Credit: Nature Neuroscience (2025). DOI: 10.1038/s41593-025-02033-x In the beginning, not even Hynek Wichterle’s postdoc thought his idea to slow the progression of amyotrophic lateral sclerosis (ALS) had a chance. “When Hynek proposed this, I