February 26, 2026

Laser heat therapy plus immunotherapy may dramatically improve survival for those with deadly brain cancer

by University of Southern California edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Glioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0 High-grade astrocytoma, which includes glioblastoma, is a fast-growing, aggressive brain cancer that often returns after the tumor is removed, making it difficult to treat. Patients with recurrent high-grade astrocytoma typically […]

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New GLP-1 pill orforglipron outperforms oral semaglutide in yearlong diabetes trial

by Lancet edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: Pixabay/CC0 Public Domain A novel GLP-1 receptor agonist (RA) pill called orforglipron leads to a larger reduction in blood sugar levels after a year than the current available oral GLP-1 RA (semaglutide), finds a phase 3 randomized controlled trial published in The

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Early birds, active folks less likely to develop ALS

by Dennis Thompson edited by Sadie Harley, reviewed by Alexander Pol  Editors’ notes  The GIST Add as preferred source Early birds and active folks are less likely to develop the degenerative brain disease called amyotrophic lateral sclerosis (ALS), a new study says. People who are early birds had a 20% lower risk of ALS—also known as Lou

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‘Off the shelf’ immunotherapy could get a lift from gene-edited natural killer cells

by Karen Guzman, Yale University edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source AI-generated image. Credit: Sidi Chen Since scientists first discovered that human immune cells could be modified to become cancer-fighting agents, they’ve been trying to engineer a cell that’s effective against solid tumors, which account for the vast

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Primary care use tied to lower mortality in patients receiving dialysis

by Lori Solomon edited by Sadie Harley, reviewed by Alexander Pol  Editors’ notes  The GIST Add as preferred source Primary care use among patients requiring hemodialysis is associated with lower mortality, according to a study published online in Kidney Medicine. Dustin Le, M.D., from Thomas Jefferson University in Philadelphia, and colleagues evaluated the association of primary care use in the

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The 5 a.m. myth: Why waking early won’t make you more successful

by Christoph Randler, The Conversation edited by Gaby Clark, reviewed by Alexander Pol  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain At 5 a.m., social media fills with proof that the early risers have already won the day. Cold plunges. Journals. Sunrise runs. Productivity gurus insist this is the routine that separates high performers

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