November 18, 2025

Evidence builds for disrupted mitochondria as cause of Parkinson’s

by Sarah C.P. Williams, Gladstone Institutes edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Gladstone’s Ken Nakamura (right) led a study that strengthens the links between energy breakdown in cells and the onset of Parkinson’s, potentially illuminating new paths for treatment. Here, Nakamura discusses the findings with Szu-Chi Liao (left) and Kohei Kano (middle), co-first authors […]

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Non-opioid pain relief: Brain’s ‘cleanup crew’ reveals a new target

by Danielle Michaud, Texas A&M University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes The research team discovered that reduced autophagy—the cell’s housekeeping system—in a specific region of the brain increases pain, prompting them to develop a novel peptide to restore balance. Credit: Texas A&M University Chronic pain is a daily reality for millions of Americans,

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Next-generation microbiome medicine may transform Parkinson’s treatment

by Amy H. Carter, University of Georgia edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes This illustration created by the Education Resources Center in the UGA College of Veterinary Medicine visualizes the biotherapeutic Levodopa being synthesized in the gut and traveling to the brain in a steady, continuous stream. Credit: Grace Caroline Herzberg/UGA CVM Educational Resources

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Researchers find simple way to make kale healthier by pairing it with oil-based dressings

by Sara Diedrich, University of Missouri edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes Credit: Food Nutrition (2025). DOI: 10.1016/j.fnutr.2025.100049 Think that kale salad you’re eating is a superfood? Without the right ingredient it might not be living up to its hype. But don’t worry. Researchers at the University of Missouri have discovered a simple (and delicious) way

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Gene ‘switch’ reverses Alzheimer’s risk in experimental model

by Hillary Smith, University of Kentucky edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Credit: Pixabay/Pete Linforth. University of Kentucky researchers have developed a new experimental model that could point the way toward more effective Alzheimer’s disease treatments by targeting one of the brain’s most important genes for risk and resilience. The study, published in Nature Neuroscience, focuses

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Simple test brings clarity and hope for families with inherited neuropathy

by Mark Michaud, University of Rochester Medical Center edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes Credit: Unsplash/CC0 Public Domain A new, inexpensive urine test that measures two sugar alcohols, sorbitol and xylitol, is making it easier, faster, and far less expensive to identify a common inherited nerve disorder called SORD-related neuropathy. The test, developed through

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Aging spleen creates toxic environment that forces T cells into self-protective but weakened state, study shows

by Technion – Israel Institute of Technology edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Illustration: The aging spleen does not properly break down red blood cells, resulting in the accumulation of toxic molecules. The solution, as mentioned, is an iron infusion Credit: Created in BioRender. Lab, R. (2025) Researchers at the Technion—Israel Institute of Technology

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Q&A: Hand, foot, and mouth disease cases are rising nationwide

by University of California – Riverside edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes Dr. E. Caroline McGowan is a board-certified pediatrician with UCR Health and an assistant clinical professor of pediatrics at the UC Riverside School of Medicine. Credit: UCR Health. Hand, foot, and mouth disease (HFMD) is a viral infection usually seen in children

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Scientists identify two key targets of common cold virus

by Tom Rickey, Pacific Northwest National Laboratory edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes An illustration of a common cold virus (left) attacking a cell.  Credit: Timothy Holland | Pacific Northwest National Laboratory Scientists were pleased when they learned more about how the common cold gains a foothold in the body, identifying key cellular checkpoints

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Pneumocystis pneumonia is striking unexpected patient groups, study shows

by National Taiwan University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Seven-year trend showing the rising proportion of Pneumocystis pneumonia cases occurring in patients without established high-risk medications (orange) or predisposing diseases (green). By 2023, nearly 70% of cases fell outside traditional risk categories, highlighting a critical gap in current prevention guidelines. Credit: National Taiwan

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