October 7, 2025

Gene linked to beta cell identity loss may explain type 2 diabetes progression

October 7, 2025 / Research update / InnovateMed Author / type 2 diabetes

by City of Hope National Medical Center edited by Sadie Harley, reviewed by Robert Egan Editors’ notes RNA velocity, splicing and trajectories in scRNA-seq and snRNA-seq data of islets from adult human non-diabetic donors. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-62670-5 Scientists at City of Hope have uncovered a gene called SMOC1 that plays a surprising role in the development of […]

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Background genetic variants can lead to different clinical features in complex disorders

October 7, 2025 / Research update / InnovateMed Author / complex disorders

by Sam Sholtis, Pennsylvania State University edited by Gaby Clark, reviewed by Robert Egan Editors’ notes New research helps explain why disease-associated genetic variants can lead to variable clinical outcomes, influenced both by the patterns of secondary variants, or genetic background, and by how cohorts of individuals in a study are ascertained. In a family (left), secondary variants

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Scientists reverse Alzheimer’s in mice using nanoparticles

October 7, 2025 / Alzheimer's disease, Research update / InnovateMed Author / alzheimer

by Institute for Bioengineering of Catalonia edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Credit: Institute for Bioengineering of Catalonia (IBEC) A research team co-led by the Institute for Bioengineering of Catalonia (IBEC) and West China Hospital Sichuan University (WCHSU), working with partners in the UK, has demonstrated a nanotechnology strategy that reverses Alzheimer’s disease in

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Novel drug combination offers hope for men with advanced prostate cancer

October 7, 2025 / Cancer, Research update / InnovateMed Author / prostate cancer

by University College London edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Credit: Unsplash/CC0 Public Domain A new drug combination could significantly delay the progression of a life-threatening form of prostate cancer in men with specific genetic mutations, finds a major international trial led by UCL researchers. The Phase III AMPLITUDE trial, published in Nature Medicine, tested

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New book shows how narrative therapy gives meaning to life

October 7, 2025 / Clinical Practice / InnovateMed Author / narrative therapy

by Columbia University edited by Lisa Lock, reviewed by Andrew Zinin Editors’ notes Credit: Columbia University Press Around the world, growing populations of older adults need social care. Aging is typically associated with steady physical and cognitive decline; the practice of narrative therapy, by contrast, focuses on the resilience of older adults by encouraging the construction of meaningful

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Five-patient lupus CAR T-cell feasibility test claims positive short-term results

October 7, 2025 / Research update / InnovateMed Author / lupus CAR T cells

by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Credit: Pixabay/CC0 Public Domain Researchers at the First Affiliated Hospital of the University of Science and Technology of China claim that an in vivo CD8 T-cell-targeted lipid nanoparticle carrying CD19 CAR mRNA (HN2301) generated transient CAR T cells that rapidly depleted B cells and

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How does your immune system stay balanced? A Nobel Prize-winning answer

October 7, 2025 / Research update / InnovateMed Author / immune system

by Aimee Pugh Bernard, The Conversation edited by Lisa Lock, reviewed by Andrew Zinin Editors’ notes Regulatory T cells suppress immune responses using a variety of molecular signals. Credit: Giwlz/Wikimedia Commons, CC BY-SA Every day, your immune system performs a delicate balancing act, defending you from thousands of pathogens that cause disease while sparing your body’s own healthy cells. This careful

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Drug discovery platform yields optimized compound against SARS-CoV-2 and shows promise against other RNA-based viruses

October 7, 2025 / Research update / InnovateMed Author / drug discovery, RNA-based viruses, SARS-CoV-2

by University of Florida edited by Stephanie Baum, reviewed by Robert Egan Editors’ notes Credit: Journal of the American Chemical Society (2025). DOI: 10.1021/jacs.5c11898 In a quest to develop new antiviral drugs for COVID-19 and other diseases, a collaboration led by scientists at The Wertheim UF Scripps Institute has identified a potential new drug against the virus that causes COVID-19.

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What matters most to senior citizens? Not what you might think

October 7, 2025 / Research update / InnovateMed Author / senior citizens

by Case Western Reserve University edited by Sadie Harley, reviewed by Andrew Zinin Editors’ notes Credit: Pixabay/CC0 Public Domain You might expect that senior citizens treated at walk-in care clinics would say what matters most to them is their health. But you’d be wrong. No question, their health is right up there. But “social activities and inclusiveness” are

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How hair and skin characteristics affect brain imaging: Making fNIRS research more inclusive

October 7, 2025 / Research update / InnovateMed Author / brain imaging

by Ingrid Fadelli, Phys.org edited by Sadie Harley, reviewed by Robert Egan Editors’ notes How the researchers collected their experimental data. Credit: Yucel et al. Functional near-infrared spectroscopy (fNIRS) is a promising non-invasive neuroimaging technique that works by detecting changes in blood oxygenation linked to neural activity using near-infrared light. Compared to fMRI and various other methods commonly

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