September 29, 2025

Blood-brain barrier remains resilient in widely used Alzheimer’s disease model, challenging previous assumptions

by Texas Tech University edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes The LMD6 laser microdissection system was used to selectively isolate distinct regions within the brain hemispheres of young and aged Tg2576 AD mice following Amytracker 680 injection. Credit: Fluids and Barriers of the CNS (2025). DOI: 10.1186/s12987-025-00685-2 A team of scientists at Texas Tech University Health […]

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Novel immunotherapy targets common cancer mutation, offering hope for lung and prostate cancer patients

by University of Oslo edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes Schematic illustration of the Wnt–β-catenin signaling pathway with or without exon 3-mutated β-catenin. Credit: Nature Immunology (2025). DOI: 10.1038/s41590-025-02252-1 Researchers at the University of Oslo and Oslo University Hospital have developed a promising new immunotherapy targeting the CTNNB1 gene mutation associated with various aggressive cancers such

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Designer biobots made from human lung cells

A brand-new engineering approach to generate “designer” biological robots using human lung cells is underway in Carnegie Mellon University’s Ren lab. Referred to as AggreBots, these microscale living robots may one day be able to traverse through the body’s complex environments to deliver desired therapeutic or mechanical interventions, once greater control is achieved over their

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Older adults can bounce back to thriving health, study finds

by University of Toronto edited by Robert Egan  Editors’ notes Credit: Kampus Production from Pexels A new Canadian study is offering a powerful message to older adults and those who care for them: it’s never too late to bounce back. Researchers at the University of Toronto have found that nearly one in four older adults age 60

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Obesity Treatment: Study Backs Dual-Drug Strategy

Teresa Santos; Ilana Polistchuck September 26, 2025 Projections from the World Obesity Federation estimate that the number of adults living with obesity will rise from 810 million in 2020 to 1.53 billion by 2035. Among the strategies to address this challenge are anti-obesity medications such as sibutramine and topiramate. The combination of these two drugs has been

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Oral bacteria linked to Parkinson’s via the gut-brain axis

by Pohang University of Science and Technology edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Diagram of Metabolite Accumulation in the Brain and Parkinson’s disease Induction Following Oral Bacteria Colonization in the Gut. Credit: POSTECH Korean researchers have uncovered compelling evidence that oral bacteria, once colonized in the gut, can affect neurons in the brain and

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Existing drug slows progression of type 1 diabetes in newly diagnosed

By Paul McClure September 27, 2025 Facebook Twitter LinkedIn Reddit Email An old drug may be repurposed to modify the course of type 1 diabetes after diagnosis Depositphotos View 1 Images An existing transplant drug has shown promise in slowing the progression of type 1 diabetes in newly diagnosed young people, potentially paving the way for

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Hospitals’ next site-neutral battle

By Maya Goldman An illustration of a heart rate monitor with dollar signs and line graphs Illustration: Sarah Grillo / Axios Hospitals appear to be on a collision course with the Trump administration over its push to change the way Medicare pays them for certain outpatient procedures. Why it matters: Health systems stand to lose billions of

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Are Probiotics Helpful in Treating Cardiovascular Issues?

As a primary care doctor, you’re often the first clinician that patients trust to discuss cardiac issues. Not only can you assess cardiac symptoms, order diagnostic tests, and refer your patients to a cardiologist, but you can also use this front-line role to discuss other ways to treat cardiac concerns. During your consultations, you will

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Reducing MMI Dose Pre-Stop Cuts Relapse in Graves Disease

SCOTTSDALE, AZ — In patients with Graves disease, prescribing a lower maintenance dose of methimazole (MMI) before discontinuing the drug is associated with significantly higher rates of remission, compared with a higher dose, according to a new study presented at the 2025 American Thyroid Association Annual Meeting. “If further research confirms this association, these findings could contribute to

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