psoriasis

Meds Can Be Reduced by Half in Some Plaque Psoriasis Cases

PARIS — Doses of interleukin (IL)-17 and IL-23 inhibitors were safely reduced in people with plaque psoriasis who had “very stable low disease activity”; it was reported during a late-breaking news session last week at the European Academy of Dermatology and Venereology (EADV) 2025 Congress. “We showed a stepwise dose reduction of IL-17 and IL-23 inhibitors is noninferior […]

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Psoriasis: High-Dose Risankizumab Produces Rapid Response, With Durability in Some Patients

Christine Kilgore December 26, 2025 High induction doses of risankizumab — at double and quadruple the approved 150 mg dose — produced rapid and durable skin clearance in patients with moderate-to-severe plaque psoriasis while significantly reducing tissue resident memory T cells (TRM) in the just-published phase 2 KNOCKOUT study led by Andrew Blauvelt, MD, MBA. The small study randomized 20 patients to either

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Are Biologics Safe in Patients With Psoriasis and Cancer?

TOPLINE: Biologic therapies demonstrated comparable safety to conventional systemic agents in patients with psoriasis who had active cancer or recent cancer history, with similar progression and recurrence rates. METHODOLOGY: To address the limited data available on the safety of biologics in patients with cancer, researchers conducted a retrospective, active comparator-controlled surveillance study of 333 treatment

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Plant-based diets may aid symptoms of psoriasis

by Lori Solomon edited by Stephanie Baum, reviewed by Alexander Pol  Editors’ notes  The GIST Add as preferred source Consuming a greater proportion of nutrients from plant sources may aid management of psoriasis symptoms, according to a study published online Feb. 19 in the European Journal of Nutrition. Sylvia Zanesco, Ph.D., from King’s College London, and colleagues assessed macronutrient intakes

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Treating psoriasis without side effects: Light-activated molecules demonstrate potential

by Spanish National Research Council edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Graphical abstract. Credit: ACS Central Science (2025). DOI: 10.1021/acscentsci.5c00987 Researchers from the Institute for Advanced Chemistry of Catalonia (IQAC) of the Spanish National Research Council (CSIC) have developed a series of light-activatable drug candidates that could serve as a

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Weight-Loss Interventions Linked to Decreased Psoriasis Severity and Improved Quality of Life

Edited by Vineeta Teotia January 01, 2026   TOPLINE: In a systematic review and meta-analysis, weight-loss interventions demonstrated clinically meaningful improvements in psoriasis severity and quality of life of patients. METHODOLOGY: Researchers conducted a systematic review and meta-analysis of 13 studies with 14 comparisons including 1145 patients with psoriasis (mean age, 49.7 years; 37.5% women; BMI, 30.8)

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Psoriasis study shows link between fat metabolism and skin inflammation for first time

by Medical University of Vienna edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Representative images of H&E staining of back skin (left) and histological quantification of the dermal white adipose tissue (DWAT) area (right). Credit: Cell Death & Differentiation (2025). DOI: 10.1038/s41418-025-01630-4 A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered

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Psoriasis caused by changes in the fat metabolism of skin cells

Download PDF Copy  Reviewed Medical University of ViennaDec 11 2025 A research team led by Erwin F. Wagner from the Medical University of Vienna has discovered a previously unknown molecular mechanism that contributes to the development of psoriasis – and at the same time represents a potential biomarker for a new treatment concept. The study published

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For Moderate-to-Severe Psoriasis, Novel Oral Therapy Acts Like a Biologic in Phase 3 Trial

Ted Bosworth November 12, 2025 Icotrokinra, a novel oral interleukin (IL)-23 inhibitor, provided a level of response in moderate-to-severe plaque psoriasis that is similar to that previously reported with injectable biologics, according to 16-week results from a newly published phase 3 trial. In a population with a median baseline Psoriasis Area and Severity Index (PASI)

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Psoriasis-linked gene mutation also impacts gut health, scientists discover

by VIB (the Flanders Institute for Biotechnology) edited by Sadie Harley, reviewed by Robert Egan Graphical abstract. Credit: EMBO Molecular Medicine (2025). DOI: 10.1038/s44321-025-00321-4 A mutation previously linked to skin disorders like psoriasis may also play a surprising role in gut health, according to new research published by scientists at VIB-UGent and colleagues from UGent, the University of Barcelona, and

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