Research from São Paulo State University shows that an inexpensive, easy-to-produce substance eliminated lung infection in 30 days. The compound has the potential to reduce the time and toxicity of current therapies Peer-Reviewed Publication Fundação de Amparo à Pesquisa do Estado de São Paulo An iron-based compound encapsulated in lipid nanoparticles completely eliminated tuberculosis in […]
by Microbiology Society edited by Sadie Harley, reviewed by Robert Egan Editors’ notes The GIST Add as preferred source Pre-activation of alveolar-like macrophages with IFN-γ and MTb cues reduces their capacity to restrict C. neoformans growth. Credit: Ross et al. (2025) Cryptococcus neoformans is one of four fungi classified as “critical priority” on the WHO’s Fungal Pathogens Priority List,
The study’s findings appear in the journal Antimicrobial Agents and Chemotherapy. Jessica L. Reynolds, associate professor of medicine in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo, is senior author on the paper. The paper details the development of an inhalable, immunomodulating, biocompatible nanoparticle system encapsulating rifampin, one of the most
NEW TUBERCULOSIS TREATMENT IS INHALABLE Read More »
by UT Southwestern Medical Center Editors’ notes The GIST Add as preferred source Credit: Cell Reports (2025). DOI: 10.1016/j.celrep.2025.116653 A study led by UT Southwestern Medical Center researchers has found that certain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide. Published in Cell Reports, the study identified characteristics of these antibodies and
Antibodies block bacteria that cause tuberculosis, study shows Read More »
by Nicola Wittekindt, German Center for Infection Research edited by Lisa Lock, reviewed by Robert Egan Editors’ notes Credit: Pixabay/CC0 Public Domain Antimicrobial stewardship (AMS) refers to coordinated strategies for the targeted, evidence-based, and safe use of anti-infective agents. The aim is to improve treatment outcomes, minimize side effects, and prevent the development and spread of antimicrobial resistance.
New clinical standards strengthen antimicrobial stewardship in tuberculosis care Read More »
Sorfequiline, previously known as TBAJ-876, was evaluated in combination with pretomanid and linezolid in a randomized, controlled trial in people with drug-sensitive TB Reports and Proceedings TB Alliance COPENHAGEN (November 19, 2025)—New clinical trial results presented by TB Alliance at the Union World Conference on Lung Health show that the novel antibiotic candidate sorfequiline (TBAJ-876),
Phase 2 clinical trial results show potential to shorten TB treatment time Read More »
by Wits University edited by Sadie Harley, reviewed by Robert Egan Editors’ notes Credit: Unsplash/CC0 Public Domain A new nano-based drug delivery technology could outwit tuberculosis (TB)—one of humanity’s most ancient diseases. At the Wits Advanced Drug Delivery Platform (WADDP), postdoctoral researcher Dr. Lindokuhle Ngema is developing an inhalable nanosystem to transport TB medicines directly into the lungs,
Breathing new life into tuberculosis treatment with inhalable nanomedicine Read More »
New UBC study reveals benztropine’s potential to treat the world’s deadliest infectious disease and combat growing antibiotic resistance. Brett Goldhawk Aug 12, 2025 Mycobacterium tuberculosis (green) inside human immune cells known as macrophages. Credit: Av-Gay Lab. A medication developed in the 1950s to treat Parkinson’s disease may offer a powerful new tool in the fight
Seventy-year-old Parkinson’s drug shows promise against tuberculosis Read More »
by Ashley Vargo, Texas A&M University edited by Gaby Clark, reviewed by Robert Egan X-ray crystal structures of Pks13-AT with SuFEx inhibitors. Credit: Nature (2025). DOI: 10.1038/s41586-025-09286-3 Scientists have developed a new compound that could offer a breakthrough in the global fight against tuberculosis, history’s deadliest infectious disease. A study recently published in Nature describes the treatment potential of the novel compound
by Albert Rizzo edited by Sadie Harley, reviewed by Andrew Zinin Tuberculosis (TB) was the leading cause of death in the United States in the 19th and 20th centuries. By 1900, TB—which usually attacks the lungs but can affect almost any part of the body—had killed one in seven people who had ever lived, more than
Tuberculosis is back on the rise: What to know about symptoms and treatment Read More »
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