T cells

New tracking tool reveals how T cells adapt in different organs

by Katherine Fenz, Rockefeller University edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Tracking of pathogen-specific CD4+ T cells during intestinal and respiratory infection. Credit: Nature Immunology (2026). DOI: 10.1038/s41590-026-02451-4 Our immune system relies on T cells to fight infections. But T cells don’t just show up and react—first, they train, get a […]

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Sequencing method can analyze millions of T cells at a fraction of the cost

by St. Jude Children’s Research Hospital edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes Development and optimization of TIRTL-seq protocol. Credit: Nature Methods (2025). DOI: 10.1038/s41592-025-02907-9 Studying T cells, the immune cells most responsible for responding to infections and cancers, just received a significant boost in the form of a new technique from St. Jude Children’s Research Hospital.

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Not all immune cells are created equal: Memory T cells in tissues outlast those in blood

by Shelby Conn, Lawrence Livermore National Laboratory edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.07.001 Memory T cells are a special type of white blood cell that “remember” past infections and vaccines, helping our bodies to quickly respond if we encounter the same germs again. These cells are found throughout the body: some

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AI-Designed Proteins Can Boost Production of T Cells

Posted Today Artist’s rendition of a ribbon diagram representing a protein structure. Image: Miyako Nakamura/iStock/Getty Images Plus Artificially designed proteins may be able to boost the production of immune cells, particularly T cells that fight cancer and harmful infections, according to new research from Harvard Medical School and Boston Children’s Hospital. The work, conducted in laboratory

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How HIV uses T cells to hide in the gut

by Mallory Locklear, Yale University edited by Sadie Harley, reviewed by Robert Egan   Graphical abstract. Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.07.022 Antiretroviral treatments for HIV (human immunodeficiency virus) have been extremely successful in extending life expectancy and reducing transmission. But one major challenge has so far prevented researchers from developing a cure: HIV likes to hide. With consistent use, antiretroviral

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