Stem cell models reveal how epilepsy genes disrupt different brain regions
by Tiare Dunlap, University of California, Los Angeles edited by Stephanie Baum, reviewed by Robert Egan Microscopy image of a human stem cell-derived hippocampal organoid. When the tissue carries an epilepsy-causing variant in the SCN8A gene, inhibitory neurons (seen in red) are disrupted, and hippocampal brainwave activity patterns are altered. Credit: Kevin Lozano, Ranmal Samarasinghe Lab For families […]
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