pulmonary fibrosis

by Jordan Shaked, Yale University edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes Credit: Sauler Lab / Yale School of Medicine Idiopathic pulmonary fibrosis (IPF) is a chronic disease in which healthy lung tissue is gradually replaced by scar tissue. While the early events that initiate this change are poorly understood, recent research suggests that the

by Inka Burow, Hannover Medical School edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Investigated how preserving the protective caps for our genetic material can improve lung health: molecular biologist Dr Shambhabi Chatterjee (right) and lead author Dr Jia Li Ye. Credit: Karin Kaiser/MHH Pulmonary fibrosis—also known in technical terms as idiopathic pulmonary fibrosis (IPF)—is a

by The Spanish National Cancer Research Centre edited by Gaby Clark, reviewed by Robert Egan Pot1aL261S/L261S knock-in MEFs show short telomeres. (A) Alignment of human POT1 and mouse POT1a and POT1b protein sequences using the Align tool of UniProt. Credit: Genes & Development (2025). DOI: 10.1101/gad.352855.125 A research group from the National Cancer Research Center (CNIO) has found that an alteration

by University of Illinois at Chicago edited by Stephanie Baum, reviewed by Robert Egan Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.04.004 For a long time, physicians and scientists believed our lungs were sterile (germ-free). But modern science indicates otherwise. Now we know they contain allergens, bacteria or viruses we inhale, such as influenza or SARS-COV-2, the virus that causes COVID-19. When those

“Our findings establish novel connections between aging biology and IPF pathogenesis while demonstrating the potential of AI-guided approaches in therapeutic development for age-related diseases.” Peer-Reviewed Publication Impact Journals LLC image: Figure 2. Comparison of biological age predictions between healthy controls and cases of severe COVID-19 infection. (A) Proteomic aging clock shows R2=0.84 in the task of age