neuroblastoma

by Erika Svantesson, Lund University edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes Credit: EMBO Molecular Medicine (2025). DOI: 10.1038/s44321-025-00349-6 Using machine learning and a large volume of data on genes and existing drugs, researchers at Lund University in Sweden have identified a combination of statins and phenothiazines that is particularly promising in the treatment of the aggressive […]

by St. Jude Children’s Research Hospital edited by Lisa Lock, reviewed by Robert Egan Models for neuroblastoma cell plasticity and the working mechanism of indisulam. Credit: Nature Communications (2025). DOI: 10.1038/s41467-025-63979-x. https://www.nature.com/articles/s41467-025-63979-x Gene expression governs whether neuroblastoma tumor cells exist in either the adrenergic (differentiated and sensitive to treatment) or mesenchymal (less differentiated and therapy-resistant) cell state. Tumors may switch

by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan GD2–CART01 toxicities. MRI evidence of the T2/FLAIR alterations observed in two patients that developed grade 3 ICANS (top-left and bottom-left) and their complete resolution (top-right and bottom-right). Credit: Nature Medicine (2025). DOI: 10.1038/s41591-025-03874-6 From Bambino Gesù Children’s Hospital in Rome comes a report that a third-generation CAR T