multiple sclerosis

Oral bacterium tied to disability severity in multiple sclerosis

by Hiroshima University edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Credit: Unsplash/CC0 Public Domain Increasing evidence suggests that the severe gum disease, periodontitis, may contribute to central nervous system disorders through chronic inflammation. However, its role in multiple sclerosis, a chronic autoimmune disease of the central nervous system, has been unclear. A research team has […]

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The role of neuroinflammation in progressive multiple sclerosis

by Ingrid Fadelli, Medical Xpress edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes OxPC deposition induces chronic demyelination, neuroinflammation, endogenous lipid peroxidation and neurodegeneration in the CNS. Credit: Nature Neuroscience (2025). DOI: 10.1038/s41593-025-02113-y. Multiple sclerosis (MS) is a disorder that prompts the body’s immune system to attack myelin, the protective sheath covering nerve cells in the brain, optic

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Using over-the-counter antioxidant to treat progressive multiple sclerosis shows mixed results

by Oregon Health & Science University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Rebecca Spain, M.D., M.S.P.H., is lead author on a new randomized controlled clinical trial testing the over-the-counter supplement lipoic acid in treating progressive forms of multiple sclerosis. Credit: Oregon Health & Science University/Christine Torres Hicks The over‐the‐counter supplement lipoic acid may have

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A fatal mix-up: How certain gut bacteria drive multiple sclerosis

by University of Basel edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Credit: AI-generated image If gut bacteria are too similar to the protective layer of nerves, they can misdirect the immune system and cause it to attack its own nervous system. This mechanism can accelerate the progression of multiple sclerosis, as researchers at the University

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Clinicians now have powerful new tools to diagnose multiple sclerosis earlier

by Ellen Goldbaum, University at Buffalo edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes This image of the brain of a 45-year-old female with secondary-progressive MS indicates with a white arrow the presence of a paramagnetic rim lesion. The image was obtained using Quantitative Susceptibility Mapping (QSM), an advanced MRI technique that can detect these lesions. Credit: University

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Multiple sclerosis explained: Symptoms, risk factors and treatments

by Dr. Aaron Bower, Assistant Professor of Neurology at Yale School of Medicine edited by Stephanie Baum, reviewed by Andrew Zinin  Editors’ notes Multiple sclerosis (MS) is one of the most common autoimmune diseases affecting the brain and spinal cord, with 2.9 million people estimated to be living with the disease worldwide. As MS is an autoimmune

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U Iowa study links multiple sclerosis with distinct oral microbiome

Comprehensive genetic and metabolic profile from saliva may help diagnose, treat MS Peer-Reviewed Publication University of Iowa Health Care image: Ashutosh Mangalam, PhD, UI professor of pathology, led a study showing that people with multiple sclerosis have a distinct, dysbiotic oral microbiome. The differences may help doctors develop new ways to diagnose, monitor and even

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How multiple sclerosis harms a brain long before symptoms appear

by University of California, San Francisco edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes In the human brain, neurofilament light chain (NfL, shown in brown) is seen in brain cells and the neural wires that connect them. UCSF researchers found NfL in the bloodstream of patients who would go on to develop multiple sclerosis years later,

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Multidisciplinary study finds estrogen could aid in therapies for progressive multiple sclerosis

by Rae Lynn Mitchell, Texas A&M University edited by Lisa Lock, reviewed by Andrew Zinin  Editors’ notes Credit: Journal of Neuroimmunology (2025). DOI: 10.1016/j.jneuroim.2025.578698 About 100,000 of the estimated million people in the United States with multiple sclerosis (MS) have a progressive form of the disease, with symptoms that worsen continuously or after periods of remission. “Progressive MS is profoundly challenging because

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Breakthrough compounds may reverse nerve damage caused by multiple sclerosis

Science News from research organizations Breakthrough compounds may reverse nerve damage caused by multiple sclerosis Scientists may have found the key to reversing multiple sclerosis damage with two groundbreaking compounds. Date: October 11, 2025 Source: University of California – Davis Summary: Researchers have identified two compounds, K102 and K110, that could repair the nerve damage

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