melanoma

A fungus living in our body can make melanoma more aggressive

by University of the Basque Country edited by Stephanie Baum, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Candida albicans effect in melanoma cells phenotype. Credit: Scientific Reports (2025). DOI: 10.1038/s41598-025-24055-y Cancer is one of the causes responsible for the most deaths worldwide. In 2020, for example, it resulted in ten million deaths. It has been […]

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Inhalable therapy aims for one-two punch against advanced melanoma

Columbia Biomedical Engineer Ke Cheng has developed a technique that delivers two therapeutic proteins directly to the lungs. Peer-Reviewed Publication Columbia University School of Engineering and Applied Science image: A color-enhanced microscope image showing an exosome (in blue) with PD-1 proteins on its surface (in brown). The black arrow points to the ring of PD-1.

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Tattoos could be a risk factor for melanoma

by Åsa Hansdotter, Lund University edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes Credit: cottonbro studio from Pexels An increasing number of Swedes are getting tattoos and Sweden’s population is now one of the most tattooed in Europe. At the same time, the incidence of melanoma is increasing. A new epidemiological study from Lund University in

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Triggering cell death in metastatic melanoma may pave the way for new cancer treatments

by Harvard T.H. Chan School of Public Health edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Credit: Unsplash/CC0 Public Domain Metastatic melanoma cells that have spread to lymph nodes survive by relying on a protein called ferroptosis suppressor protein 1 (FSP1)—a surprising metabolic dependency that could open the door to a new class of cancer treatments,

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DNA copy-number changes help melanoma develop resistance to immunotherapy, study finds

by Denise Heady, University of California, Los Angeles edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Credit: Illustration by the Roger Lo Laboratory. A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators reveals how melanoma, the deadliest form of skin cancer, evolves to resist immunotherapy and identifies a potential strategy to prevent or reverse

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Promising drug combinations for immunotherapy-resistant melanoma may also help reactivate immune system

by Sutter Health edited by Stephanie Baum, reviewed by Robert Egan Credit: Journal of Clinical Investigation (2025). DOI: 10.1172/jci185220 Researchers at Sutter’s California Pacific Medical Center (CPMC) in San Francisco, Calif. have identified potential new therapeutic strategies for patients with advanced melanoma who no longer respond to immunotherapy—an aim representing one of the most pressing clinical challenges in cancer care

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Melanoma ‘cellular compass’ discovery could help curb metastasis

by Center for Genomic Regulation edited by Sadie Harley, reviewed by Robert Egan eIF2A at the centrosome (white). Credit: Jennifer Jungfleisch/Centro de Regulación Genómica Researchers have discovered a protein which is critical for steering melanoma cancer cells as they spread throughout the body. The malignant cells become dependent on this protein to migrate, pointing to new strategies for

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