lupus

Approved IV drug reduces lupus symptoms, clinical trial finds

by Dennis Thompson edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source An already-approved IV drug significantly reduces the symptoms of lupus, a new clinical trial showed. More than three-quarters of lupus patients taking obinutuzumab (Gazvya) had a significant improvement in their symptoms after a year on the drug, researchers […]

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Navigating the Skin-Related Variants of Lupus

Doug Brunk November 08, 2025 SAN ANTONIO — Distinguishing between the various forms of cutaneous lupus can be challenging, even for experienced clinicians. If a patient presents with a malar rash — also known as a butterfly rash — think acute cutaneous lupus until proven otherwise. “ That’s nearly always associated with systemic lupus,” Amanda

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CD21 downregulation found to trigger harmful B cells in lupus

by Sanjukta Mondal, Medical Xpress edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Representative whole-spleen IF images at 1 and 5 d.p.t. CD45.1 channel removed in insets with colors as in (G). Scale bars, 1 mm and 200 μm (inset). Credit: Danni Y. Zhu Our body’s immune system is quick to spring into action when it

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Scientists tie lupus to a virus nearly all of us carry

by Stanford University Medical Center edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes This electron microscopic image of two Epstein Barr Virus virions (viral particles) shows round capsids—protein-encased genetic material—loosely surrounded by the membrane envelope. Credit: PloS Biology (2005), DOI: 10.1371/journal.pbio.0030430.g001 One of humanity’s most ubiquitous infectious pathogens bears the blame for the chronic autoimmune condition called systemic

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Could CAR-T therapy be a cure for lupus? Early trials show promise

by Dr. Amit Saxena edited by Sadie Harley, reviewed by Alexander Pol Systemic lupus erythematosus (SLE) is a complex autoimmune disease with a spectrum of very different manifestations and variable severity. This makes the condition difficult to diagnose and treat, with the goal of putting the disease into remission more so than curing it. The most common

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Aging dampens lupus by reducing overactive immune genes in older adults

by University of California, San Francisco edited by Sadie Harley, reviewed by Andrew Zinin Credit: CC0 Public Domain UCSF researchers have found that certain antiviral genes become less active over time in lupus, revealing why some patients see their symptoms fade as they age. Lupus, an autoimmune disease, causes the immune system’s first-line viral defenses—known as interferons—to attack

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Up to 40 years to get diagnosed with lupus: Research highlights devastating impact of delays on patients

by Swansea University edited by Andrew Zinin   Credit: Pixabay/CC0 Public Domain New research by Swansea University and Cambridge University has revealed the causes and devastating impacts of delays—that can last decades—in diagnosing lupus, an auto-immune condition. The average diagnostic delay—time from first lupus symptoms to lupus diagnosis—among study participants was 7.5 years, with one patient having

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