Linking lactate metabolism to muscle GDF15 release during mitochondrial stress
From lactate to GDF15: a muscle stress response to mitochondrial damage Peer-Reviewed Publication Science China Press image: Mitochondrial DNA (mtDNA) mutations impair OXPHOS and enhance lactate accumulation in skeletal muscle. Elevated lactate drives H3K14 histone lactylation, inducing GDF15 expression and secretion in mitochondrial myopathy. view more Credit: ©Science China Press Growth differentiation factor 15 (GDF15) has […]
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