fatty liver disease

Peer-Reviewed PublicationThe Hebrew University of Jerusalem image: Prof. Joseph (Yossi) Tam view more  Credit: (Credit- Tom Barnea) Researchers have discovered that non-psychoactive cannabis compounds, CBD and CBG, can significantly reduce liver fat and improve metabolic health. The study reveals that these compounds work by creating a backup energy reserve in the liver and restoring the activity […]

by Hanyang University edited by Gaby Clark, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Endoplasmic reticulum stress and unfolded protein response dysregulation propel lifestyle-associated fatty liver disease (metabolic dysfunction-associated steatotic liver disease, affecting 30% globally) from simple steatosis to metabolic dysfunction-associated steatohepatitis, cirrhosis, and hepatocellular carcinoma, via mechanisms like IRE1-driven lipotoxicity, cell death,

Xia & He Publishing Inc. Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a predominant chronic liver condition globally, intricately linked with obesity, type 2 diabetes (T2DM), and metabolic syndrome. Its pathogenesis is complex, following a “multiple-hit” hypothesis that involves triglyceride accumulation, insulin resistance (IR), lipotoxicity, chronic inflammation, and oxidative stress. Among the various