dopamine

by Molly Chiu, Baylor College of Medicine edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Manipulation of pigmentation enzymes has unexpected effects on dopamine. Credit: iScience (2026). DOI: 10.1016/j.isci.2025.114388 Dopamine in the brain influences movement, learning, motivation and sleep. In humans, problems with dopamine are linked to conditions like Parkinson’s disease, depression […]

by Jared Wadley, University of Michigan edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes VTADA neuronal activity during NREM sleep is modulated by enriched multisensory salient experiences but not by predator-related salient experiences. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adw7427 Dopamine neurons—the cells that drive reward and motivation while we’re awake—become surprisingly active during nonrapid eye movement sleep right after

by Karolinska Institutet edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes Illustration depicting a model of how DA and serotonin cotransmission shapes behavior through frequency-dependent filtering of D1-MSN axons. Credit: Science Advances (2025). DOI: 10.1126/sciadv.adx4577 Researchers at Karolinska Institutet, Columbia University and the University of San Francisco, have uncovered a previously unknown mechanism by which dopamine, a key