deafness

Detailed structure of key hearing protein points way to optimizing gene therapies for deafness

by Lena Bösch, University Medical Center Göttingen edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes Schematic representation of otoferlin with a ring-shaped arrangement of its individual C2 domains (colored on the left and right) and transmembrane domain (light blue) anchoring it in the synaptic vesicle (indicated as a gray semicircle). Through the interaction of otoferlin with the […]

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Gene therapy restores hearing in deaf patients

by Karolinska Institutet edited by Sadie Harley, reviewed by Robert Egan   Credit: Pixabay/CC0 Public Domain Gene therapy can improve hearing in children and adults with congenital deafness or severe hearing impairment, a new study involving researchers at Karolinska Institutet reports. Hearing improved in all 10 patients, and the treatment was well-tolerated. The study, “AAV gene therapy for autosomal

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