cystic fibrosis

by Ian Scheffler, University of Pennsylvania edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source A visualization of the A3G editor’s crystalline structure, with red arrows indicating locations the engineers modified to change their affinity for binding to DNA. Making the editor more accurate could lead to applications like treatments for […]

by Tiare Dunlap, University of California, Los Angeles edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Characterization of lipid nanoparticles (LNPs) loaded with CFTR-editing cargoes. Credit: Advanced Functional Materials (2026). DOI: 10.1002/adfm.202502540 UCLA researchers have developed a lipid nanoparticle-based gene-editing approach capable of inserting an entire healthy gene into human airway cells,

by University of New South Wales edited by Lisa Lock, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source An artistic rendering of airway organoids spiralling around DNA, capturing how each child’s unique biology shapes their path to the right cystic fibrosis treatment. Credit: Shafagh Waters When UNSW Associate Professor Shafagh Waters explains cystic fibrosis

by Ty Tkacik, Pennsylvania State University edited by Gaby Clark, reviewed by Robert Egan The team’s sensor is capable of measuring and reporting the chloride ion levels of a subject’s sweat in real time with high precision and efficiency. Credit: Caleb Craig/Penn State Sweat does more than just cool down an overheating body. Measuring the chemical makeup of an