childhood disease

Inhibiting programmed cell death to treat a rare childhood disease

by University of Cologne edited by Gaby Clark, reviewed by Robert Egan   Credit: Unsplash/CC0 Public Domain A team of researchers at the University of Cologne’s Center for Biochemistry, together with the Bambino Gesù Pediatric Hospital in Rome, Italy, have discovered a fundamental biological mechanism that directly connects the immune sensor protein STING to inflammatory cell death. The […]

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Liquid fat treatment offers hope for rare childhood disease

by University of Queensland edited by Lisa Lock, reviewed by Robert Egan   Triheptanoin as an anaplerotic agent feeding into the TCA cycle. This schematic illustrates triheptanoin metabolism and its anaplerotic role in the TCA cycle. Triheptanoin, a triglyceride of heptanoate, replenishes the tricarboxylic acid (TCA) cycle via acetyl CoA and propionyl-CoA which is converted to succinyl-CoA. Credit: eBioMedicine (2025).

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