January 26, 2026

Bringing Optical Color to Ultrasound

Through a clever combination of two imaging modalities, scientists from Caltech and USC have developed a new technique that can quickly provide 3D color images that capture both the structure of soft tissues and details of how the blood vessels are functioning. The researchers have used the new technique to successfully image multiple parts of […]

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Regenerating lost lymph nodes with bioengineered tissues

by Tokyo University of Science edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Researchers engineer centrifuge-based lymphatic tissue for the treatment of secondary lymphedema that occurs after lymphadenectomy. Credit: Associate Professor Kosuke Kusamori / Tokyo University of Science, Japan The rising incidence of cancer worldwide has led to an increasing

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High-dose inhaled nitric oxide shows early promise as a potential antimicrobial therapy

by Mass General Brigham edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: CC0 Public Domain Overuse of antibiotics has accelerated the development of bacterial resistance to conventional drugs, a global health crisis projected to result in more than 10 million deaths annually by 2050. The multidrug-resistant bacterium Pseudomonas aeruginosa

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Prediabetes: Blood-based epigenetic markers enable more precise risk assessment

by German Center for Diabetes Research edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Schematic representation summarizing different steps of the current study and the cohorts. Two independent groups of participants are included; a discovery and a replication cohort. Credit: Biomarker Research (2026). DOI: 10.1186/s40364-025-00887-8 Prediabetes is an extremely heterogeneous metabolic disorder.

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Advancing the realization of oral insulin using novel peptide technology

by Kumamoto University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Engineered DNP peptides—either fused to insulin-binding peptides or covalently linked to insulin using click chemistry—directly enhanced insulin absorption in mice. These findings demonstrate that DNP peptides are versatile carriers for the oral delivery of macromolecular drugs, offering a practical

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Neuronal activity reveals new clues to ALS progression

by Roni Dengler, Thomas Jefferson University edited by Robert Egan  Editors’ notes  The GIST Add as preferred source Credit: American Journal of Physiology-Cell Physiology (2025). DOI: 10.1152/ajpcell.00238.2025 Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no cure and limited treatment options. One of the earliest signs of ALS is overactive brain signals known as cortical hyperexcitability. This

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Tiny molecules called tRNA halves may contribute to prostate cancer cell growth

by Moriah Adde, Thomas Jefferson University edited by Robert Egan  Editors’ notes  The GIST Add as preferred source Knockdown of the 5′-tRNALysCUU half suppresses cell cycle progression. Credit: PLOS Biology (2025). DOI: 10.1371/journal.pbio.3003194 Prostate cancer is the second-most common cancer in men. A new study from Thomas Jefferson University uncovered a new potential therapeutic target in tiny molecules called tRNA

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From diagnosis to treatment and care: Understanding mesothelioma

by David Hill edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Mesothelioma is a rare type of cancer, most often caused by exposure to asbestos, according to the U.S. Centers for Disease Control and Prevention (CDC). Mesothelioma develops in the thin tissue surrounding the lungs and other internal organs.

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Single gene found to influence gut bacteria balance and IBD susceptibility

by Iqbal Pittalwala, University of California – Riverside edited by Andrew Zinin  Editors’ notes  The GIST Add as preferred source Credit: Unsplash/CC0 Public Domain Two recent studies from the University of California, Riverside, published in the same issue of Gut Microbes highlight the role of a gene called PTPN2 in protecting the gut from harmful bacteria linked to inflammatory

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Many Patients May Keep Off Lost Pounds After Stopping a GLP-1, US Data Suggests

Nancy Lapid January 22, 2026 Jan 22 (Reuters) – Many patients using highly effective GLP-1 drugs like Wegovy may not regain lost weight quickly when they stop treatment, according to an analysis of real-world data shared with Reuters that sheds light on a chief concern about the therapies. Among thousands of patients treated at a

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