October 10, 2025

Potential link between chronic pain, immune condition found

by Steve Benowitz, University of Arizona edited by Gaby Clark, reviewed by Andrew Zinin  Editors’ notes Credit: Neuromodulation: Technology at the Neural Interface (2025). DOI: 10.1016/j.neurom.2025.07.004 University of Arizona researchers may have uncovered a connection between chronic pain and a somewhat uncommon immune condition, opening the door to future research on immune biomarkers for chronic pain. A small study […]

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Can a new blood test really detect ME/CFS? An expert unpacks new research

by Sarah Annesley, The Conversation edited by Sadie Harley, reviewed by Andrew Zinin  Editors’ notes Credit: Karolina Grabowska from Pexels Scientists in the United Kingdom say they have developed a blood test that can diagnose myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with 96% accuracy—the first of its kind. For many who live with the debilitating condition, this will be exciting news. Despite

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No, circumcision doesn’t cause autism

Kennedy made a wild claim during Thursday’s Cabinet meeting: “Children who were circumcised early have double the rates of autism.” He then said it’s “highly likely” that these findings are linked to Tylenol use, before adding “none of this is positive.” It is unclear where the secretary’s information is coming from. There are two studies that look at

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Exposure to Commonly Used Chemical Tied to Parkinson’s Disease Risk –

Long-term exposure to high levels of the industrial degreasing chemical trichloroethylene (TCE) was associated with an increased risk for Parkinson’s disease (PD), a new study showed. Using data from the US Environmental Protection Agency (EPA) National Air Toxics Assessment, researchers found that individuals exposed to higher TCE concentrations in outside air were 10% more likely

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Experimental drug findings pave way for clinical trial to target cancer’s elusive growth switch

by The Francis Crick Institute edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes (A) Chemical structure of VVD ligands used in the manuscript. (B) Global proteomics selectivity of VVD-484, VVD-849, VVD-579, and VVD-844. Cells were treated with 10 µM of VVD-484, 2 µM of VVD-849 or VVD-579, or 1 µM of VVD-844, which is ~25-fold over

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‘Smart insulin’ shows promise in reducing hypoglycemia bouts

by Indiana University edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes Credit: ACS Pharmacology & Translational Science (2025). DOI: 10.1021/acsptsci.5c00362 Researchers at the Indiana University School of Medicine have discovered a new way to regulate blood glucose levels using a lab-designed protein, possibly opening the door to a new treatment avenue for people with type 1 diabetes. The

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Portable device could help scientists track Alzheimer’s disease as it unfolds in real time

by Concordia University edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes Schematic of microfluidic cell adhesion assay. a Photo of the microfluidic device; the microchannel and reservoirs were filled with red dye (scale bar= 25 mm). b dimensions of the microchannel and reservoirs (top view). c 3D Experimental setup and d side view of device when the PBS flow was pumped into the device

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Kidney cancer drug shows promise against dangerous calcium imbalance caused by tumors

by UT Southwestern Medical Center edited by Gaby Clark, reviewed by Robert Egan  Editors’ notes PT2399/belzutifan disrupts HIF-2α binding to HIF-1β, thereby blocking its ability to bind DNA and stimulate the production of PTHrP, the hormone responsible for calcium induction in kidney cancer patients. Credit: UT Southwestern Medical Center Elevated calcium levels in the blood—a complication of kidney cancers known

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FDA approves Zoryve for atopic dermatitis in young children

by Lori Solomon edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes Credit: Unsplash/CC0 Public Domain The U.S. Food and Drug Administration has approved the supplemental new drug application for Zoryve (roflumilast) cream 0.05% for the topical treatment of mild-to-moderate atopic dermatitis in children 2 to 5 years of age. The once-daily cream can be used

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New research reveals genetic link to most common pediatric bone cancer

by Cleveland Clinic edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes Credit: Unsplash/CC0 Public Domain Researchers at Cleveland Clinic Children’s have helped identify a previously unknown gene that increases the risk of developing osteosarcoma, the most common type of malignant bone tumor in children and young adults. In work published in the Journal of Clinical Oncology, researchers analyzed genetic

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