September 16, 2025

Investigators pave the way for next-generation TB vaccine

September 16, 2025 / Research update / InnovateMed Author / TB vaccine

by Jacqueline Mitchell, Beth Israel Lahey Health edited by Sadie Harley, reviewed by Robert Egan Graphical abstract. Credit: Cell (2025). DOI: 10.1016/j.cell.2025.08.027 Tuberculosis, or TB, an airborne bacterial respiratory infection, is one of humanity’s oldest foes and is today the world’s leading cause of death from infectious disease, claiming more than 1.2 million lives each year. The single available […]

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The Rumpelstiltskin effect as a therapeutic intervention

September 16, 2025 / Research update / InnovateMed Author / Rumpelstiltskin effect

by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan Credit: AI-generated image James Madison University and Case Western Reserve University researchers describe a phenomenon they term the Rumpelstiltskin effect, in which the act of receiving a clinical diagnosis itself produces therapeutic benefit independent of medical intervention. Across medicine, diagnostic terms that are technically descriptive rather

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September 16, 2025 / Research update / InnovateMed Author / catch 22 of aging

by Stowers Institute for Medical Research edited by Gaby Clark, reviewed by Robert Egan A model of death fold domains (green) that are templating a caspase (blue) to kill the cell after it has been compromised by pathogens. Credit: Stowers Institute for Medical Research Some of our biggest threats can come in the tiniest forms—viruses and bacteria.

Unique brain cell may hold key to Alzheimer’s disorientation

September 16, 2025 / Research update / InnovateMed Author / alzheimer disorientation

by Jared Wadley, University of Michigan edited by Lisa Lock, reviewed by Robert Egan Retrosplenial low rheobase (LR) cells have a dramatically different cholinergic receptor (Chrm) expression pattern compared to other glutamatergic cell types in RSG. Credit: Progress in Neurobiology (2025). DOI: 10.1016/j.pneurobio.2025.102804 Losing your sense of direction is one of the earliest and most distressing signs of advanced Alzheimer’s

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Six ways to talk to your teens about sex without the cringe

September 16, 2025 / Patient education / InnovateMed Author / sex

by Jennifer Power, Alexandra James, Thomas Norman, The Conversation edited by Lisa Lock, reviewed by Andrew Zinin Credit: Pixabay/CC0 Public Domain Parents play an important role in teaching their children about sex and relationships. But our new report shows many parents—fathers in particular—find it mortifying. Our national survey of 1,918 parents shows they are most likely to be very confident talking

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About one in five people taking Ozempic, Wegovy or Mounjaro say food tastes saltier or sweeter than before

September 16, 2025 / Patient education / InnovateMed Author / Ozempic

by European Association for the Study of Diabetes edited by Stephanie Baum, reviewed by Robert Egan Credit: Pixabay/CC0 Public Domain New research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15–19 September) shows that some individuals who are taking Ozempic, Wegovy or Mounjaro find that foods taste

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Digital cognitive test offers early Alzheimer’s screening in primary care

September 16, 2025 / Research update / InnovateMed Author / alzheimer screening

by Lund University edited by Lisa Lock, reviewed by Robert Egan Credit: Pixabay/CC0 Public Domain Alzheimer’s disease is the most common cause of dementia. As new disease-modifying treatments for Alzheimer’s disease are now becoming available, both early and accurate diagnosis in a resource-efficient assessment process are becoming increasingly important, as not everyone responds to the new drugs.

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GD2 CAR T treatment induces durable remissions in high-risk neuroblastoma

September 16, 2025 / Research update / InnovateMed Author / neuroblastoma

by Justin Jackson, Phys.org edited by Sadie Harley, reviewed by Robert Egan GD2–CART01 toxicities. MRI evidence of the T2/FLAIR alterations observed in two patients that developed grade 3 ICANS (top-left and bottom-left) and their complete resolution (top-right and bottom-right). Credit: Nature Medicine (2025). DOI: 10.1038/s41591-025-03874-6 From Bambino Gesù Children’s Hospital in Rome comes a report that a third-generation CAR T

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Newly identified immune response controls Oropouche infection and prevents neurological damage

September 16, 2025 / Research update / InnovateMed Author / oropouche infection

By Luciana Constantino, FAPESP edited by Sadie Harley, reviewed by Robert Egan B cells in the marginal zone of the spleen are the first lymphocytes to act in the body after infection, rapidly producing antibodies that prevent the virus from spreading. Credit: Daniel Teixeira et al./eBioMedicine) Research conducted on mice has identified that the rapid response of

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New autoinjector could save lives in severe bleeding emergencies

September 16, 2025 / Research update / InnovateMed Author / bleeding emergencies

by Hebrew University of Jerusalem edited by Lisa Lock, reviewed by Robert Egan Credit: Injury (2025). DOI: 10.1016/j.injury.2025.112721 A new study shows that a TXA autoinjector delivers lifesaving treatment for severe bleeding as effectively as traditional IV methods—but in under five minutes and without the need for medical expertise. This breakthrough could transform trauma care in emergencies, making rapid, easy-to-administer

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