June 24, 2025

Weekly semaglutide improves blood sugar and weight in adults with type 1 diabetes, clinical trial finds

by Oregon Health & Science University edited by Robert Egan   Credit: Unsplash/CC0 Public Domain A new clinical trial found that taking a popular diabetes and weight-loss drug once weekly significantly improves blood sugar and leads to substantial weight loss in adults with type 1 diabetes who use automated insulin delivery systems. The results are published today in the […]

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Macrophages elicit separate pathways for inflammation and lysosomal function in diseases due to toxic particle exposure

by Jeff Hansen, University of Alabama at Birmingham edited by Robert Egan   Graphical abstract. Credit: Immunity (2025). DOI: 10.1016/j.immuni.2025.02.023 Human exposure to toxic particles drives various diseases. Examples include gout, an acute arthritis driven by monosodium urate crystals, or MSUc; CPPD disease, another inflammatory joint disease driven by calcium pyrophosphate dihydrate crystals, or CPPDc; and the lung disease

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Pill-on-a-thread’ could replace endoscopies for half of all patients being monitored for esophageal cancer risk

by University of Cambridge edited by Sadie Harley, reviewed by Robert Egan   Professor Rebecca Fitzgerald demonstrates the capsule sponge. Credit: StillVision Endoscopies could be replaced by far less invasive capsule sponge tests for half of all patients with Barrett’s esophagus, a known precursor to esophageal cancer, according to a new study by researchers at the University of

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Fixing problems in cholesterol metabolism could stave off a leading cause of blindness

by Washington University in St. Louis edited by Sadie Harley, reviewed by Robert Egan   Fixing problems with cholesterol metabolism might help slow or prevent a common cause of age-related vision loss, a new WashU Medicine study in mice has shown. Pictured are color-stained retinal epithelial cells from a mouse eye, the first cells to die as age-related

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Popular diabetes and weight-loss drug may reduce risk of dementia

by Case Western Reserve University edited by Sadie Harley, reviewed by Robert Egan Credit: Unsplash/CC0 Public Domain Researchers at the Case Western Reserve School of Medicine have found that semaglutide, a popular diabetes and weight-loss drug, may lower the risk of dementia in people with type 2 diabetes (T2D). Dementia, a condition that slowly makes it harder for

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Can monoclonal antibodies effectively treat malaria? Scientists say the answer is a resounding ‘yes’

by Delthia Ricks, Phys.org edited by Sadie Harley, reviewed by Robert Egan   Credit: Pixabay/CC0 Public Domain Monoclonal antibodies provide protection against a wide range of infectious microbes, and now, in a series of elegant laboratory experiments, scientists have uncovered how a pair of these lab-engineered molecules fight malaria. The newly developed antibodies have arrived at a critical

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Newborns have elevated levels of a biomarker for Alzheimer’s

by University of Gothenburg edited by Lisa Lock, reviewed by Robert Egan Credit: Brain Communications (2025). DOI: 10.1093/braincomms/fcaf221 Newborn babies and patients with Alzheimer’s disease share an unexpected biological trait: elevated levels of a well-known biomarker for Alzheimer’s, as shown in a study led by researchers at the University of Gothenburg and published in Brain Communications. First author Fernando Gonzalez-Ortiz and senior author

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New PET imaging method simplifies coronary artery disease detection

by Society of Nuclear Medicine and Molecular Imaging edited by Sadie Harley, reviewed by Andrew Zinin   Exercise/rest measurements of the standardized uptake value ratio (SUVR) are used with an exponential calibration function to estimate myocardial flow reserve (MFR). This allows (i) the physiological information from the exercise stress to be combined with (ii) the proven value

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Alzheimer’s Protective Mutation Works by Taming Inflammation in the Brain

June 23, 2025 Share to Facebook  Share to Twitter  Share to LinkedIn  Share on Email The Christchurch mutation in the APOE3 gene protects against tauopathy by tamping down inflammation in the brain. Credit: The Gan lab. A rare gene mutation that delays Alzheimer’s disease does so by damping inflammatory signaling in brain-resident immune cells, according

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