June 23, 2025

Unveiling cutting-edge advances in CAR-T cell therapy for lymphoma

June 23, 2025 / Research update / InnovateMed Author / lymphoma

Peer-Reviewed Publication Tsinghua University Press FacebookXLinkedInWeChatBlueskyMessageWhatsAppEmail CAR-T cells, which are genetically programmed to specifically recognize and kill target cells, have altered the therapeutic landscape of lymphoma. After the tumor antigens are identified by scFv, CAR-T cells execute anti-tumor activity through granzyme and perforin secretion, inducing cell apoptosis in a Fas-FasL-dependent pathway and producing inflammatory cytokines […]

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Closed loop’ learning barriers prevent doctors from using life-saving bedside ultrasound

June 23, 2025 / Clinical Practice / InnovateMed Author / Ultrasound

by University of Cambridge edited by Gaby Clark, reviewed by Andrew Zinin Credit: Pixabay/CC0 Public Domain Many doctors abandon a potentially life-saving medical scanning technology soon after training, because systemic barriers prevent it from becoming part of their routine practice, a study published in Advances in Health Sciences Education has found. Point-of-care ultrasound (POCUS) enables doctors to perform rapid bedside scans

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Antibiotics and energy inhibitors effectively kill aggressive melanoma cells by blocking mitochondrial pathways

June 23, 2025 / Research update / InnovateMed Author / melanoma cells

by Wiley edited by Sadie Harley, reviewed by Robert Egan Mitochondria. Credit: Wikipedia commons Researchers have discovered that the most aggressive melanomas, the deadliest form of skin cancer, overactivate two key processes in mitochondria, the components of cells that provide energy. Blocking these pathways with currently available drugs effectively killed melanoma cells. The findings are published in Cancer.

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AI helps researchers understand lung disease and proposes treatment

June 23, 2025 / Research update / InnovateMed Author / lung disease

by Gillian Dohrn, Yale School of Medicine edited by Lisa Lock, reviewed by Robert Egan UNAGI overview. Credit: Nature Biomedical Engineering (2025). DOI: 10.1038/s41551-025-01423-7 The secrets of idiopathic pulmonary fibrosis (IPF) are written in its very name. Idiopathic refers to a disease of unknown cause, and the condition, which turns healthy lung tissue into fibrous scar tissue, still raises

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California has had more measles cases so far this year than in all of 2024

June 23, 2025 / Patient education / InnovateMed Author / measles

by Harriet Blair Rowan edited by Sadie Harley, reviewed by Andrew Zinin Illustration of the virus which causes measles. Credit: CDC/ Allison M. Maiuri, MPH, CHES This month, the number of measles cases reported in California so far in 2025 jumped above the total for all of 2024. There have been 16 measles cases reported in the Golden

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GLP-1’s next frontier: migraines

June 23, 2025 / News update / InnovateMed Author / migraine

As someone who used to experience 15 migraines a month, I am thrilled to write this item: Migraines are the next test case for the blockbuster GLP-1 drugs that have gained remarkable popularity for treating diabetes and obesity. A pilot study presented at a conference Friday found that GLP-1 agonists reduced monthly migraine days by almost half, which the

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Zimislecel Enables Insulin Independence in 10 Participants with Type 1 Diabetes

June 23, 2025 / Research update / InnovateMed Author / insulin

Zimislecel Enables Insulin Independence in 10 Participants with Type 1 Diabetes Author(s): Victoria Johnson Fact checked by: Patrick Campbell Conference|American Diabetes Association Listen Key Takeaways Zimislecel therapy led to insulin independence in 83% of participants with type 1 diabetes after one year. Participants showed significant improvements in glycemic control, with HbA1c levels below

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Team discovers how tiny parts of cells stay organized, adding new insights for blocking cancer growth

June 23, 2025 / Research update / InnovateMed Author / cancer growth

by City of Hope National Medical Center edited by Andrew Zinin Credit: Pixabay/CC0 Public Domain A team of international researchers led by scientists at City of Hope provides the most thorough account yet of an elusive target for cancer treatment. Published in Science Advances, the study suggests a complex signaling process involving paxillin, a focal adhesion protein

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Metabolic dysfunction-associated steatotic liver disease linked to risk for sudden hearing loss

June 23, 2025 / Research update / InnovateMed Author / liver disease

by Elana Gotkine edited by Gaby Clark, reviewed by Andrew Zinin Among older adults, metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with increased risk for sudden sensorineural hearing loss (SSNHL), according to a study published in the June issue of Laryngoscope: Investigative Otolaryngology. Eun Seok Kang, M.D., from the Korea University College of Medicine in Seoul, and colleagues

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One Psilocybin Dose Eases Cancer Depression Over Long Term

June 23, 2025 / Clinical Practice / InnovateMed Author / cancer depression

A single dose of psilocybin combined with psychological support can provide lasting relief from depression and anxiety in patients with cancer. In a phase 2 clinical trial, more than half of patients reported sustained reductions in depression, and nearly half reported significant reductions in anxiety 2 years after treatment. Psilocybin is a “potentially paradigm-shifting alternative

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