T cell

by Kyoto University edited by Sadie Harley, reviewed by Robert Egan  Editors’ notes  The GIST Add as preferred source Active aldehydes shape metabolic exhaustion in T cells. Credit: Koji Kitaoka Cancer immunotherapy is a type of cancer treatment that harnesses the immune system to fight cancer cells. The treatment involves CD8⁺ T cells, also known as killer T […]

by Max Delbrück Center for Molecular Medicine edited by Robert Egan  Editors’ notes T stem cells normally undergo asymmetric cell division (left) whereby one daughter cell becomes a long-lived memory T cell. When autophagy is disrupted, both daughter cells inherit old mitochondria (red) and become effector T-cells (right). Credit: University of Oxford When killer T cells of

by Ecole Polytechnique Federale de Lausanne edited by Stephanie Baum, reviewed by Robert Egan  Editors’ notes Credit: Unsplash/CC0 Public Domain Cancer immunotherapy, especially using T cells, is showing a lot of promise in treating blood cancers. Bioengineered T cells, especially those equipped with chimeric antigen receptors (CAR-T cells), have revolutionized cancer treatment. But while they’ve delivered impressive results

by Yale School of Medicine edited by Stephanie Baum, reviewed by Andrew Zinin  Editors’ notes Figure S1 RelA (NFB) translocation into nucleus during synapse formation. (A) Representative images from live-cell imaging data over 1 hour of CTL expressing NLS-iRFP670 (nucleus, white in upper panels), DsRed-PACT domain (centrosome, red, yellow arrowhead), and RelA EGFP (transcription factor NFKB, cyan in